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dc.contributor.authorFuente García, Miguel Ángel de la es
dc.contributor.authorPizcueta, Pilar
dc.contributor.authorNadal, Marga
dc.contributor.authorBosch, Jaime
dc.contributor.authorEngel, Pablo
dc.date.accessioned2015-04-10T11:10:55Z
dc.date.available2015-04-10T11:10:55Z
dc.date.issued1997
dc.identifier.citationBlood,1997, Vol 90, No 6, pp 2398-2405es
dc.identifier.issn0006-4971es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/10379
dc.descriptionProducción Científicaes
dc.description.abstractcDNA isolated from a human B-cell line Raji library was ana- (CD48 and HumLy9) have been mapped. CD84 monoclonal lyzed and shown to encode the full-length cDNA sequence antibodies (MoAbs) were shown to react with cells transof a novel cell-surface glycoprotein, initially termed HLy9-b. fected with the cloned cDNA. These MoAbs were further The predicted mature 307-amino acid protein was composed used to show that CD84 is expressed as a single chain cellof two extracellular Ig-like domains, a hydrophobic trans- surface glycoprotein of Mr 64,000 to 82,000, which was membrane region, and an 83-amino acid cytoplasmic do- highly glycosylated. CD84 had a unique pattern of expresmain. The extracellular Ig-like domains presented structural sion, being found predominantly on lymphocytes and monoand sequence homology with a group of members of the Ig cytes. Thus, the glycoprotein HLy9-b is recognized by MoAbs superfamily that included CD2, CD48, CD58, and Ly9. North- previously clustered as CD84 and represents a newly identiern blot analysis showed that the expression of HLy9-b was fied member of the Ig superfamily that may play a significant predominantly restricted to hematopoietic tissues. Chromo- role in leukocyte activation.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society of Hematologyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHematologíaes
dc.subjectCélulas hematopoyéticas
dc.titleCD84 leukocyte antigen is a new member of the Ig superfamilyes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.publicationfirstpage2398es
dc.identifier.publicationissue6es
dc.identifier.publicationlastpage2405es
dc.identifier.publicationtitleBloodes
dc.identifier.publicationvolume90es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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