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dc.contributor.authorVila, Mercedes
dc.contributor.authorGarcía, Ana
dc.contributor.authorGirotti, Alessandra
dc.contributor.authorAlonso Rodrigo, Matilde 
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorGonzález Vázquez, Arlyng
dc.contributor.authorPlanell i Estany, Josep A.
dc.contributor.authorEngel López, Elisabeth
dc.contributor.authorBuján Varela, Julia
dc.contributor.authorGarcía Honduvilla, Natalio
dc.contributor.authorVallet Regí, María
dc.date.accessioned2016-12-14T09:43:48Z
dc.date.available2016-12-14T09:43:48Z
dc.date.issued2016
dc.identifier.citationActa Biomaterialia 2016, Elsevier, vol. 45, p. 349–356es
dc.identifier.issn1742-7061es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/21699
dc.descriptionProducción Científicaes
dc.description.abstractThe current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) func- tionalized surfaces. Silicon doped hydroxyapatite (Si-HA), with Ca10(PO4)5.7(SiO4)0.3(OH)1.7h0.3 nominal formula, was surface functionalized with two different types of polymers designed by genetic engineer- ing: ELR-RGD that contain cell attachment specific sequences and ELR-SNA15/RGD with both hydroxya- patite and cells domains that interact with the inorganic phase and with the cells, respectively. These hybrid materials were subjected to in vitro assays in order to clarify if the ELRs coating improved the well-known biocompatible and bone regeneration properties of calcium phosphates materials. The in vitro tests showed that there was a total and homogeneous colonization of the 3D scaffolds by Bone marrow Mesenchymal Stromal Cells (BMSCs). In addition, the BMSCs were viable and able to proliferate and differentiate into osteoblasts.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiomateriales - Aplicaciones médicases
dc.title3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicinees
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttp://dx.doi.org/10.1016/j.actbio.2016.09.016es
dc.relation.publisherversionhttp://www.sciencedirect.comes
dc.identifier.publicationfirstpage349es
dc.identifier.publicationlastpage356es
dc.identifier.publicationvolume45es
dc.peerreviewedSIes
dc.description.projectMinisterio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R)
dc.description.projectMinisterio de Ciencia e Innovación (proyectos MAT2012-35556 y MAT2009-14195-C03-02)
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA313U14)
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/642687
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/646075
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/278557
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/317306
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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