Skip navigation
Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/22788
Título: Determination of the temporal order among the components of an oscillatory system
Autor: Barragán, Sandra
Rueda, Cristina
Fernández, Miguel
Peddada, Shyamal
Año del Documento: 2015
Documento Fuente: PLOS ONE 10(7): e0124842
Resumen: Oscillatory systems in biology are tightly regulated process where the individual components (e.g. genes) express in an orderly manner by virtue of their functions. The temporal order among the components of an oscillatory system may potentially be disrupted for various reasons (e.g. environmental factors). As a result some components of the system may go out of order or even cease to participate in the oscillatory process. In this article, we develop a novel framework to evaluate whether the temporal order is unchanged in different populations (or experimental conditions). We also develop methodology to estimate the order among the components with a suitable notion of “confidence.” Using publicly available data on S. pombe, S. cerevisiae and Homo sapiens we discover that the temporal order among the genes cdc18; mik1; hhf1; hta2; fkh2 and klp5 is evolutionarily conserved from yeast to humans.
Revisión por Pares: SI
DOI: 10.1371/journal.pone.0124842
Patrocinador: Ministerio de Ciencia e Innovación grant (MTM2012-37129)
Junta de Castilla y León, Consejería de Educación
European Social Fund within the Programa Operativo Castilla y León 2007–2013
Intramural Research Program of the National Institute of Environmental Health Sciences (Z01 ES101744-04)
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/22788
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP24 - Artículos de revista

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
journal.pone.0124842.pdf575,04 kBAdobe PDFThumbnail
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons

Comentarios
Universidad de Valladolid
Powered by MIT's. DSpace software, Version 5.5