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dc.contributor.authorBarriuso, Begoña
dc.contributor.authorJiménez López, María del Pilar 
dc.contributor.authorCordoba Diaz, Manuel
dc.contributor.authorCordoba Diaz, Damián
dc.contributor.authorGirbés Juan, Tomás 
dc.contributor.authorArias Vallejo, Francisco Javier 
dc.contributor.authorGirotti, Alessandra
dc.date.accessioned2017-07-14T09:23:22Z
dc.date.available2017-07-14T09:23:22Z
dc.date.issued2016
dc.identifier.citationToxins vol.8, issue 6, 2016es
dc.identifier.issn2072-6651es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/24415
dc.descriptionProducción Científicaes
dc.description.abstractEndoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature. Targeting endoglin with immunotoxins containing type 2 ribosome-inactivating proteins has proved an effective tool to reduce blood supply to B16 mice tumor xenografts. We prepared anti-endoglin immunotoxin (IT)—containing recombinant musarmin 1 (single chain ribosome-inactivating proteins) linked to the mouse anti-human CD105 44G4 mouse monoclonal antibody via N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP). The immunotoxin specifically killed L929 fibroblast mouse cells transfected with the short form of human endoglin with IC50 values in the range of 5 × 10−10 to 10−9 M.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classificationCánceres
dc.subject.classificationTerapia antitumorales
dc.titleAnti-Human Endoglin (hCD105) Immunotoxin—Containing Recombinant Single Chain Ribosome-Inactivating Protein Musarmines
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.3390/toxins8060184es
dc.relation.publisherversionhttp://www.mdpi.com/2072-6651/8/6/184es
dc.peerreviewedSIes
dc.description.projectCICYT BIO98-0727es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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