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dc.contributor.authorGovindharajulu, Jeevan Prasaad
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorBattacharya, Mrinal
dc.contributor.authorAparicio, Conrado
dc.date.accessioned2017-07-14T09:53:03Z
dc.date.available2017-07-14T09:53:03Z
dc.date.issued2017
dc.identifier.citationInternational Journal of Molecular Sciences 2017, 18 (2), 369;es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/24420
dc.descriptionProducción Científicaes
dc.description.abstractThe main clinical problems for dental implants are (1) formation of biofilm around the implant—a condition known as peri-implantitis and (2) inadequate bone formation around the implant—lack of osseointegration. Therefore, developing an implant to overcome these problems is of significant interest to the dental community. Chitosan has been reported to have good biocompatibility and anti-bacterial activity. An osseo-inductive recombinant elastin-like biopolymer (P-HAP), that contains a peptide derived from the protein statherin, has been reported to induce biomineralization and osteoblast differentiation. In this study, chitosan/P-HAP bi-layers were built on a titanium surface using a layer-by-layer (LbL) assembly technique. The difference in the water contact angle between consecutive layers, the representative peaks in diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), X-ray photoelectron spectroscopy (XPS), and the changes in the topography between surfaces with a different number of bi-layers observed using atomic force microscopy (AFM), all indicated the successful establishment of chitosan/P-HAP LbL assembly on the titanium surface. The LbL-modified surfaces showed increased biomineralization, an appropriate mouse pre-osteoblastic cell response, and significant anti-bacterial activity against Streptococcus gordonii, a primary colonizer of tissues in the oral environmentes
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classificationImplante dentales
dc.titleChitosan-recombinamer layer-by-layer coatings for multifunctional implantses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.3390/ijms18020369es
dc.relation.publisherversionhttp://www.mdpi.com/journal/ijmses
dc.peerreviewedSIes
dc.description.projectMinisterio de Economía, Industria y Competitividad (Project MAT2013-42473-R and MAT2015-68901R)es
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13, VA313U14 and VA015U16)es
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/278557
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/317306
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/642687
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/646075
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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