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dc.contributor.authorSingh, Smriti-
dc.contributor.authorRahimi, Khosrow-
dc.contributor.authorFechete, Radu-
dc.contributor.authorRodríguez Cabello, José Carlos-
dc.contributor.authorMöller, Martin-
dc.identifier.citationSoft Matter, 2016,12, pg. 6240-6252es
dc.descriptionProducción Científicaes
dc.description.abstractInvestigation of the aggregation behavior of biohybrid microgels, which can potentially be used as drug carriers, is an important topic, because aggregation not only causes loss of activity, but also toxicity and immunogenicity. To study this effect we synthesized microgels from elastin-like recombinamers (ELRs) using the miniemulsion technique. The existence of aggregation for such biohybrid microgels at different concentrations and temperatures was studied by different methods which include dynamic light scattering (DLS), 1H high-resolution magic angle sample spinning (HRMAS) NMR spectroscopy, relaxometry and diffusometry. A hysteresis effect was detected in the process of aggregation by DLS as a function of temperature that strongly depends on ELR microgel concentration. The aggregation process was further quantitatively analyzed by the concentration dependence of the 1H amino-acid residue chemical shifts and microgel diffusivity measured by NMR methods using the population balance kinetic aggregation
dc.publisherRoyal Society of Chemistryes
dc.subject.classificationAgregación de microgeles biohíbridoses
dc.titleAggregation behaviour of biohybrid microgels from elastin-like recombinamerses
dc.description.projectMinisterio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R).es
Appears in Collections:Documentos OpenAire(Open Access Infrastructure for Research in Europe)
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