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dc.contributor.authorSingh, Smriti
dc.contributor.authorRahimi, Khosrow
dc.contributor.authorFechete, Radu
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorMöller, Martin
dc.date.accessioned2017-07-28T08:37:09Z
dc.date.available2017-07-28T08:37:09Z
dc.date.issued2016
dc.identifier.citationSoft Matter, 2016,12, pg. 6240-6252es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/24800
dc.descriptionProducción Científicaes
dc.description.abstractInvestigation of the aggregation behavior of biohybrid microgels, which can potentially be used as drug carriers, is an important topic, because aggregation not only causes loss of activity, but also toxicity and immunogenicity. To study this effect we synthesized microgels from elastin-like recombinamers (ELRs) using the miniemulsion technique. The existence of aggregation for such biohybrid microgels at different concentrations and temperatures was studied by different methods which include dynamic light scattering (DLS), 1H high-resolution magic angle sample spinning (HRMAS) NMR spectroscopy, relaxometry and diffusometry. A hysteresis effect was detected in the process of aggregation by DLS as a function of temperature that strongly depends on ELR microgel concentration. The aggregation process was further quantitatively analyzed by the concentration dependence of the 1H amino-acid residue chemical shifts and microgel diffusivity measured by NMR methods using the population balance kinetic aggregation model.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherRoyal Society of Chemistryes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classificationAgregación de microgeles biohíbridoses
dc.titleAggregation behaviour of biohybrid microgels from elastin-like recombinamerses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1039/C6SM00954Aes
dc.relation.publisherversionhttp://pubs.rsc.org/en/content/articlelanding/2016/sm/c6sm00954aes
dc.peerreviewedSIes
dc.description.projectMinisterio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R).es
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/642687
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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