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dc.contributor.authorGarcía, María
dc.contributor.authorPoza Crespo, Jesús 
dc.contributor.authorSantamarta, David
dc.contributor.authorRomero-Oraá, Roberto
dc.contributor.authorHornero Sánchez, Roberto 
dc.date.accessioned2018-09-03T09:30:48Z
dc.date.available2018-09-03T09:30:48Z
dc.date.issued2018
dc.identifier.citationPhilosophical Transactions of The Royal Society A-Mathematical Physical and Engineering Sciences, vol. 376 (2126), pp. 20170251es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/31347
dc.descriptionProducción Científicaes
dc.description.abstractNormal pressure hydrocephalus (NPH) encompasses a heterogeneous group of disorders generally characterised by clinical symptoms, ventriculomegaly and anomalous cerebrospinal fluid (CSF) dynamics. Lumbar infusion tests (ITs) are frequently performed in the preoperatory evaluation of patients who show NPH features. The analysis of intracranial pressure (ICP) signals recorded during ITs could be useful to better understand the pathophysiology underlying NPH and to assist treatment decisions. In this study, 131 ICP signals recorded during ITs were analysed using two continuous wavelet transform (CWT)-derived parameters: Jensen Divergence (JD) and Spectral Flux (SF). These parameters were studied in two frequency bands, associated with different components of the signal: 𝐵"(0.15 - 0.3 Hz), related to respiratory blood pressure oscillations; and 𝐵# (0.67 - 2.5 Hz), related to ICP pulse waves. Statistically significant differences (𝑝 < 1.70 ∙ 10+,, Bonferroni-corrected Wilcoxon signed rank tests) in pairwise comparisons between phases of ITs were found using the mean and standard deviation of JD and SF. These differences were mainly found in 𝐵#, where a lower irregularity and variability, together with less prominent time-frequency fluctuations, were found in the hypertension phase of ITs. Our results suggest that wavelet analysis could be useful for understanding CSF dynamics in NPH.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherThe Royal Society Publishinges
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccesses
dc.titleContinuous wavelet transform in the study of the time-scale properties of intracranial pressure in hydrocephaluses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holderPhilosophical Transactions of The Royal Society A-Mathematical Physical and Engineering Scienceses
dc.relation.publisherversionhttp://rsta.royalsocietypublishing.org/content/376/2126/20170251es
dc.peerreviewedSIes
dc.description.projectThis research was supported by ‘Ministerio de Economía y Competitividad’ and 'European Regional Development Fund' (FEDER) under project TEC2014-53196-R, by ‘European Commission’ and FEDER under project 'Análisis y correlación entre el genoma completo y la actividad cerebral para la ayuda en el diagnóstico de la enfermedad de Alzheimer' ('Cooperation Programme Interreg V-A Spain-Portugal POCTEP 2014-2020'), and by ‘Consejería de Educación de la Junta de Castilla y León’ and FEDER under project VA037U16.es


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