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Please use this identifier to cite or link to this item: http://uvadoc.uva.es/handle/10324/31350
Title: Alterations of Effective Connectivity Patterns in Mild Cognitive Impairment: An MEG Study
Authors: Gómez, Carlos
Juan-Cruz, Celia
Poza, Jesús
Ruiz-Gómez, Saúl J.
Gomez-Pilar, Javier
Núñez, Pablo
García, María
Fernández, Alberto
Hornero, Roberto
Issue Date: 2018
Publisher: IOS Press
Description: Producción Científica
Citation: Journal of Alzheimers Disease, In Press
Abstract: Neuroimaging techniques have demonstrated over the years their ability to characterize the brain abnormalities associated with different neurodegenerative diseases. Among all these techniques, magnetoencephalography (MEG) stands out by its high temporal resolution and noninvasiveness. The aim of the present study is to explore the coupling patterns of resting-state MEG activity in subjects with mild cognitive impairment (MCI). To achieve this goal, five minutes of spontaneous MEG activity were acquired with a 148- channel whole-head magnetometer from 18 MCI patients and 26 healthy controls. Interchannel relationships were investigated by means of two complementary coupling measures: coherence and Granger causality. Coherence is a classical method of functional connectivity, while Granger causality quantifies effective (or causal) connectivity. Both measures were calculated in the five conventional frequency bands: delta (d, 1-4 Hz), theta (q, 4-8 Hz), alpha (a, 8-13 Hz), beta (b, 13-30 Hz), and gamma (g, 30-45Hz). Our results showed that connectivity values were lower for MCI patients than for controls in all frequency bands. However, only Granger causality revealed statistically significant differences between groups (p-values < 0.05, FDR corrected Mann-Whitney U-test), mainly in the beta band. Our results support the role of MCI as a disconnection syndrome, which elicits early alterations in effective connectivity patterns. These findings can be helpful to identify the neural substrates involved in prodromal stages of dementia.
Peer Review: SI
Sponsor: This research was supported by ‘Ministerio de Economía y Competitividad’ and ‘European Regional Development Fund’ under project TEC2014-53196-R, by ‘European Commission’ and ‘European Regional Development Fund’ under project ‘Análisis y correlación entre el genoma completo y la actividad cerebral para la ayuda en el diagnóstico de la enfermedad de Alzheimer’ (‘Cooperation Programme Interreg V-A Spain-Portugal POCTEP 2014-2020’), and by ‘Consejería de Educación de la Junta de Castilla y León’ under project VA037U16. Pablo Núñez was in receipt of a ‘Promoción de empleo joven e implantación de la Garantía Juvenil en I+D+i’ grant from ‘Ministerio de Economía y Competitividad’ and University of Valladolid.
Publisher Version: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad170475
Language: eng
URI: http://uvadoc.uva.es/handle/10324/31350
Rights: info:eu-repo/semantics/restrictedAccess
Appears in Collections:GIB - Artículos de revista

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