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Título: Optimized Diffusion-Weighting Gradient Waveform Design (ODGD) formulation for motion compensation and concomitant gradient nulling
Autor: Peña-Nogales, Óscar
Zhang, Yuxin
Wang, Xiaoke
Luis-Garcia, Rodrigo
Aja-Fernández, Santiago
H. Holmes, James
Hernando, Diego
Año del Documento: 2018
Editorial: Wiley
Descripción: Producción Científica
Documento Fuente: Magn. Reson. Med 2018;00:1-15
Resumen: Purpose: To present a novel Optimized Diffusion-weighting Gradient waveform Design (ODGD) method for the design of minimum echo time (TE), bulk motion-compensated, and concomitant gradient (CG)-nulling waveforms for diffusion MRI. Methods: ODGD motion-compensated waveforms were designed for various moment-nullings Mn (n=0,1,2), for a range of b-values, and spatial resolutions, both without (ODGD-Mn) and with CG-nulling (ODGD-Mn-CG). Phantom and in-vivo (brain and liver) experiments were conducted with various ODGD waveforms to compare motion robustness, signal-to-noise ratio (SNR), and apparent diffusion coefficient (ADC) maps with state-of-the-art waveforms. Results:ODGD-Mn and ODGD-Mn-CG waveforms reduced the TE of state-of-the-art waveforms. This TE reduction resulted in significantly higher SNR (P < 0.05) in both phantom and in-vivo experiments. ODGD-M1 improved the SNR of BIPOLAR (42.8+-5.3 versus 32.9+-3.3) in the brain, and ODGD-M2 the SNR of motion-compensated (MOCO) and Convex Optimized Diffusion Encoding-M2 (CODE-M2) (12.3+-3.6 versus 9.7+-2.9 and 10.2+-3.4, respectively) in the liver. Further, ODGD-M2 also showed excellent motion robustness in the liver. ODGD-M2-CG waveforms reduced the CG-related dephasing effects of non CG-nulling waveforms in phantom and in-vivo experiments, resulting in accurate ADC maps. Conclusions: ODGD waveforms enable motion-robust diffusion MRI with reduced TEs, increased SNR, and reduced ADC bias compared to state-of-the-art waveforms in theoretical results, simulations, phantoms and in-vivo experiments.
Palabras Clave: Diffusion-weighted imaging (DWI)
diffusion-weighting gradient waveforms
optimization
motion compensation
concomitant gradient (CG)-nulling
Revisión por Pares: SI
DOI: 10.1002/mrm.27462
Patrocinador: TEC2013-44194-P
VA069U16
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/31374
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP71 - Artículos de revista

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