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Please use this identifier to cite or link to this item: http://uvadoc.uva.es/handle/10324/33446
Title: Bioactive scaffolds based on elastin-like materials for wound healing
Authors: Rodríguez Cabello, José Carlos
González de Torre, Israel
Ibáñez Fonseca, Arturo
Alonso Rodrigo, Matilde
Issue Date: 2018
Publisher: Elsevier
Description: Producción Científica
Citation: Advanced Drug Delivery Reviews, 2018, Volume 129, Pages 118-133
Abstract: Wound healing is a complex process that, in healthy tissues, starts immediately after the injury. Even though it is a natural well-orchestrated process, large trauma wounds, or injuries caused by acids or other chemicals, usually produce a non-elastic deformed tissue that not only have biological reduced properties but a clear aesthetic effect. One of the main drawbacks of the scaffolds used for wound dressing is the lack of elasticity, driving to non-elastic and contracted tissues. In the last decades, elastin based materials have gained in importance as biomaterials for tissue engineering applications due to their good cyto- and bio-compatibility, their ease handling and design, production and modification. Synthetic elastin or elastin like-peptides (ELPs) are the two main families of biomaterials that try to mimic the outstanding properties of natural elastin, elasticity amongst others; although there are no in vivo studies that clearly support that these two families of elastin based materials improve the elasticity of the artificial scaffolds and of the regenerated skin. Within the next pages a review of the different forms (coacervates, fibres, hydrogels and biofunctionalized surfaces) in which these two families of biomaterials can be processed to be applied in the wound healing field have been done. Here, we explore the mechanical and biological properties of these scaffolds as well as the different in vivo approaches in which these scaffolds have been used.
Classification: Elastina
Elastin
ISSN: 0169-409X
Peer Review: SI
DOI: https://doi.org/10.1016/j.addr.2018.03.003
Sponsor: Ministerio de Economía, Industria y Competitividad (Projects MAT2015-68901-R, MAT2016-78903-R, PCIN-2015-010)
Junta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. VA015U16)
European Commission (ELASTISLET N. 646075)
Publisher Version: https://www.sciencedirect.com/science/article/pii/S0169409X18300425
Language: eng
URI: http://uvadoc.uva.es/handle/10324/33446
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:BIOFORGE - Artículos de revista

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