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dc.contributor.authorGonzález Fajardo, José Antonio
dc.contributor.authorAguirre Cervás, Beatriz
dc.contributor.authorPérez Bushardt, José Luis
dc.contributor.authorÁlvarez, Tomás
dc.contributor.authorFernández, Leopoldo
dc.contributor.authorRamos, Guillermo
dc.contributor.authorVaquero Puerta, Carlos 
dc.date.accessioned2013-09-13T08:24:01Z
dc.date.available2013-09-13T08:24:01Z
dc.date.issued1996
dc.identifier.citationJournal of Vascular Surgery, July 1996, vol. 23, num. 3 p. 446-451es
dc.identifier.issn0741-5214es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/3422
dc.descriptionProducción Científicaes
dc.description.abstractThe efficacy of epidural regional hypothermia in the prevention of acute and delayed-onset paraplegia, as well as possible complications and limitations of this technique to a clinically acceptable form, were evaluated in 49 New Zealand white rabbits. Methods: A modified rabbit spinal cord ischemia model of infrarenal aortic occlusion for 30 minutes was employed. The study was performed in two phases. In phase I (n = 20), regional hypothermia induced by epidural perfusion of iced normal saline solution (4 ~ C) was tested versus control in 10 rabbits each (groups A and B). In phase II (n = 29) the animals were subdivided into three groups to study the kinetics of absorption and distribution of methylene blue (group C; n = 10), radiographic contrast material (group D; n = 9), and measurement ofcerebrospinal pressure while an epidural iced solution was or was not infused (group E; n = 10). Results: At 24 and 48 hours, all of the normothermic animals showed irreversible paraplegia (Tarlov score 0). In contrast, at 24 hours none of the rabbits undergoing epidural cold infusion were paraplegic, although at 48 hours one animal had weakness of a hindiimb (Tarlov score 3). Plasma concentration-time profiles of a continuous epidural perfusion with methylene blue showed that the spinal canal is a highly compliant space. Epidurographs showed that epidural perfusion tends to spread more in a cephalic than caudal direction and the main uptake is by the vascular compartiiient. Despite the large volumes infused (78.75 ml/hr; range, 50 to 100 ml), we observed only a modest transient increase in cerebrospinal fluid pressure (from 2.5 -+ 0.3 mm Hg to 5.4 -+ 0.1 mm Hg), although some animals had intracranial hypertension. Conclusions: Regional hypothermia induced by epidural cold perfusion has a highly protective effect against the ischemic spinal cord damage. However, this method probably does not avoid the risk of delayed-onset paraplegia. An important limitation of this technique is the difficulty of controlling the intrathecal pressures.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherSociety of Vascular Surgeryes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectParaplegiaes
dc.subjectCardiováscular, Aparatoes
dc.titleEpidural regional hypothermia for prevention of paraplegia after aortic occlusion : experimental evaluation in a rabbit modeles
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi101016/j.jvs.2008.05.033es
dc.identifier.publicationfirstpage446es
dc.identifier.publicationissue3es
dc.identifier.publicationlastpage451es
dc.identifier.publicationtitleJournal of Vascular Surgeryes
dc.identifier.publicationvolume23es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported


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