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dc.contributor.authorFranco, Elvira
dc.contributor.authorGarcía Recio, Verónica
dc.contributor.authorJiménez López, María del Pilar 
dc.contributor.authorGarrosa García, Manuel 
dc.contributor.authorGirbés Juan, Tomás 
dc.contributor.authorCordoba Diaz, Manuel
dc.contributor.authorCordoba Diaz, Damián
dc.date.accessioned2020-06-03T12:15:48Z
dc.date.available2020-06-03T12:15:48Z
dc.date.issued2018
dc.identifier.citationToxins, 2018, vol. 10, n. 8. 9 p.es
dc.identifier.issn2072-6651es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/40987
dc.descriptionProducción Científicaes
dc.description.abstractA pyrogen is a substance that causes fever after intravenous administration or inhalation. Gram negative endotoxins are the most important pyrogens to pharmaceutical laboratories. In the International, United States, Japanese and European Pharmacopoeias, there are two official methods to evaluate pyrogenicity—that is, the bacterial endotoxin test, and the pyrogen test. The main objective of this review is to compare the monographs of each test among the different Pharmacopeias, to detect similarities and differences. The former can be considered fully harmonized, and only non-significant differences were detected. The latter, which is the only available assay for some products and formulations to demonstrate apyrogenicity, shows large differences, which should be considered.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationPyrogenses
dc.subject.classificationPirógenoses
dc.subject.classificationParenteral drug productses
dc.subject.classificationMedicamentos vía parenterales
dc.titleEndotoxins from a pharmacopoeial point of viewes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2018 MDPIes
dc.identifier.doi10.3390/toxins10080331es
dc.relation.publisherversionhttps://www.mdpi.com/2072-6651/10/8/331es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco3207.06 Endotoxinases


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