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dc.contributor.authorTellería Orriols, Juan José 
dc.contributor.authorBlanco Quirós, Alfredo
dc.contributor.authorMuntión, Sandra
dc.contributor.authorGarrote Adrados, José Antonio 
dc.contributor.authorArranz Sanz, Eduardo 
dc.contributor.authorArmentia Medina, Alicia 
dc.contributor.authorDíez, Ignacio
dc.contributor.authorCastro, Jesús
dc.date.accessioned2020-09-01T09:45:07Z
dc.date.available2020-09-01T09:45:07Z
dc.date.issued2006
dc.identifier.citationRespiratory Medicine, 2006, Volume 100, n. 6, p.1072-1078es
dc.identifier.issn0954-6111es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/42060
dc.descriptionProducción Científicaes
dc.description.abstractThe study of determinants of asthma is a subject of much interest currently, especially the pharmacogenetic aspects of asthma management. Genetic polymorphisms affecting amino-acids at positions 16 and 27 within β2-adrenoceptor (β2AR) gene have been implicated in the asthma phenotypes and influence on the variability observed in response to use of bronchodilator agents used in the treatment of asthma. Whether these polymorphisms alter the bronchoprotection response to -agonist treatment in Spanish asthmatic population is unknown. The aim of this study was to investigate whether genetic polymorphisms within β2AR gene modulate the clinical outcomes of the individual response to β2-agonist therapy and the development of desensitization in Spanish asthmatic patients.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationTaquifilaxiaes
dc.subject.classificationAsmaes
dc.subject.classificationAleloses
dc.subject.classificationPolimorfismoses
dc.titleTachyphylaxis to β2-agonists in Spanish asthmatic patients could be modulated by β2-adrenoceptor gene polymorphismses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© Elsevieres
dc.identifier.doi10.1016/j.rmed.2005.09.028es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0954611105004063es
dc.identifier.publicationfirstpage1072es
dc.identifier.publicationissue6es
dc.identifier.publicationlastpage1078es
dc.identifier.publicationtitleRespiratory Medicinees
dc.identifier.publicationvolume100es
dc.peerreviewedSIes
dc.description.projectFondo de Investigación Sanitaria y Ministerio de Sanidad, Consumo y Bienestar Social (FIS00648 and 02/3068)es
dc.description.projectJunta de Castilla y León (VA032/04)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unescomedicinaes


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