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dc.contributor.authorSánchez Romero, Diego 
dc.contributor.authorGanfornina Álvarez, María Dolores 
dc.contributor.authorGutiérrez, Gabriel
dc.contributor.authorGauthier-Jauneau, Anne-Christine
dc.contributor.authorRisler, Jean-Loup
dc.contributor.authorSalier, Jean-Philippe
dc.date.accessioned2014-09-23T17:12:32Z
dc.date.available2014-09-23T17:12:32Z
dc.date.issued2005
dc.identifier.citationAkerstrom, Bo; Borregard, Niels; Flower, Darren R.; Salier, Jean-Phillippe (coords.). Molecular Biology Intelligence Unit: Lipocalins. Georgetown: Texas, 2005, p. 5-16es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/6219
dc.descriptionProducción Científicaes
dc.description.abstractAs extensively detailed elsewhere in this book, lipocalins exibit three characteristic features, which include: (i) an unusually low amino acid sequence similarity (typically 15-25% between paralogs) (ii) a highly conserved protein tertiary structure, and (iii) a similar arrangement of exons and introns in the coding sequence of their genes. These shared protein and gene features are overwhelming arguments for the existence of a single lipocalin ancestral gene that once extended into a family. The ancestral gene appears to have arisen in a group of bacteria, and possibly was inherited by eukaryotes as a result of genome fusion (see Chapter 4). Given this hypothetical beginning, lipocalins are expected to be found in all descendants of the eukaryotic common ancestor. Currently, and aside of prokaryotes, bona fide lipocalin have been recovered from a protoctist, a fungus, several plants, a nematode, several arthropods, a tunicate, a cephalochordate, and many examples of chordates. This review will first focus on the structure of lipocalin genes in eukaryotes, and then on our current view of the evolutionary hostory of this family.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherLandes Biosciencees
dc.publisherEurekah.comes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectLipocalinases
dc.titleLipocalin Genes and Their Evolutionary Historyes
dc.typeinfo:eu-repo/semantics/bookPartes
dc.identifier.publicationfirstpage5es
dc.identifier.publicationlastpage16es
dc.identifier.publicationtitleMolecular Biology Intelligence Unit: Lipocalinses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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