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dc.contributor.author | Cayzac, A. | |
dc.contributor.author | Rocher Martín, María Asunción | |
dc.contributor.author | Obeso Cáceres, Ana María de la Luz | |
dc.contributor.author | González, Constancio | |
dc.contributor.author | Ricardi, D. | |
dc.contributor.author | Kemp, P. K. | |
dc.date.accessioned | 2014-11-12T12:46:00Z | |
dc.date.available | 2014-11-12T12:46:00Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Respiratory Physiology & Neurobiology 175 (2011) 80–89 | es |
dc.identifier.issn | 1569-9048 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/7091 | |
dc.description | Innovación Educativa | es |
dc.description.abstract | An increase in intracellular Ca2+ is crucial to O2 sensing by the carotid body. Polyamines have been reported to modulate both the extracellular Ca2+-sensing receptor (CaR) and voltage-gated Ca2+ channels in a number of cell types. Using RT-PCR and immunohistochemistry, the predominant voltage-gated Ca2+ channels expressed in the adult rat carotid body were L (CaV1.2) and N (CaV2.2)-type. CaR mRNA could not be amplified from carotid bodies, but the protein was expressed in the nerve endings. Spermine inhibited the hypoxia-evoked catecholamine release from isolated carotid bodies and attenuated the depolarization- and hypoxia-evoked Ca2+ influx into isolated glomus cells. In agreement with data from carotid body, recombinant CaV1.2 was also inhibited by spermine. In contrast, the positive allosteric modulator of CaR, R-568, was without effect on hypoxia-induced catecholamine release from carotid bodies and depolarization-evoked Ca2+ influx into glomus cells. These data show that spermine exerts a negative influence on carotid body O2 sensing by inhibiting L-type Ca2+ channels. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Respiración celular | es |
dc.title | Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1016/j.resp.2010.09.009 | es |
dc.identifier.publicationfirstpage | 80 | es |
dc.identifier.publicationlastpage | 89 | es |
dc.identifier.publicationtitle | Respiratory Physiology & Neurobiology | es |
dc.identifier.publicationvolume | 175 | es |
dc.peerreviewed | Sí | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
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