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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/7158
Título: Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
Autor: Obeso Cáceres, Ana
Gómez-Niño, María Angeles
Almaraz Gómez, Laura
Dinger, Bruce
Fidone, Salvatore
González, Constancio
Año del Documento: 1997
Editorial: Elsevier
Descripción: Producción Científica
Documento Fuente: Brain Research 754 1997. 298–302
Resumen: Current concepts on the location and functional significance of nicotinic receptors in the carotid body rest on a-bungarotoxin binding and autoradiographic studies. Using an in vitro preparation of the cat carotid body whose catecholamine deposits have been labeled by prior incubation with the tritiated natural precursor w3Hxtyrosine, we have found that nicotine induces release of w3Hxcatecholamines in a dose-dependent manner IC50s9.81 mM.. We also found that mecamylamine 50 mM. completely abolished the nicotine-induced release, while a-bungarotoxin 100 nM; f20 times its binding Kd. only reduced the release by 56%. These findings indicate that chemoreceptor cells, and perhaps other carotid body structures, contain nicotinic receptors that are not sensitive to a-bungarotoxin and force a revision of the current concepts on cholinergic mechanisms in the carotid body chemoreception.
Materias (normalizadas): Neurofisiología
Receptores celulares
ISSN: 0006-8993
Revisión por Pares: SI
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/7158
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP06 - Artículos de revista

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