2024-03-29T14:22:25Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/154142023-07-17T08:16:25Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Bustamante Munguira, Juan
Tamayo Gómez, Eduardo
Flórez, Santiago
Tellería Orriols, Juan José
Bustamante Munguira, Elena
López Díaz, Javier
San Román Calvar, José Alberto
Álvarez González, Francisco Javier
2016-01-19T09:21:12Z
2016-01-19T09:21:12Z
2011
Revista Española de Cardiología, 2011;64(11):1056–1059
1885-5857
http://uvadoc.uva.es/handle/10324/15414
10.1016/j.rec.2011.02.027
1056
11
1059
Revista Española de Cardiología
64
Producción Científica
The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide
polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4
(D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis.
The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped by
means of restriction analysis after their amplification. An association between endocarditis and variants
of TLR2 R753Q (P < .001) was observed, but no association with other polymorphisms was found.
The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant
(odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype.
The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development of
infective endocarditis. Further studies are required to validate these results and identify other genetic
risk factors.
application/pdf
eng
Elsevier
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Endocarditis
Toll-Like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis
info:eu-repo/semantics/article
SI