2024-03-28T10:23:26Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/261382021-10-21T14:27:29Zcom_10324_31661com_10324_952com_10324_894com_10324_23040com_10324_954col_10324_31662col_10324_23041
Lopes, Joana
Mustapa, Ana Najwa Binti
Pantic, Milica
Bermejo Roda, Maria Dolores
Martín Martínez, Ángel
Novak, Zoran
Knez, Zeljko
Cocero Alonso, María José
2017-10-05T10:22:29Z
2017
The Journal of Supercritical Fluids, Diciembre 2017, vol 130, p. 17-22
0896-8446
http://uvadoc.uva.es/handle/10324/26138
10.1016/j.supflu.2017.07.018
17
22
The Journal of Supercritical Fluids
130
Producción Científica
The use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m2 g−1, pore volume from 0.3 to 2.4 cm3 g−1 and pore diameter from 7.9 to 34 nm. Drug loading capacity was investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40 °C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim][DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry.
2019-07-25
2019-07-25
Junta de Castilla y León VA295U14
Marie Curie Program. Project DoHip
Ministerio de Economía. Programa Ramon y Cajal, RyC RYC-2013-13976
MOE (Ministry of Education of Malaysia)
application/pdf
eng
Elsevier B.V.
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Elsevier B.V.
Attribution-NonCommercial-NoDerivatives 4.0 International
Materiales
Supercritical
Impregnation
Aerogel
Phytol
Cellulose
Ionic liquids
Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol
info:eu-repo/semantics/article
https://doi.org/10.1016/j.supflu.2017.07.018
SI