2024-03-28T12:46:24Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/60982021-06-23T09:51:43Zcom_10324_1134com_10324_931com_10324_894col_10324_1213
Bajo Grañeras, Raquel
Crespo Sanjuan, Jesús
García Centeno, Rosa María
Garrote Adrados, José Antonio
Gutiérrez, Gabriel
García Tejeiro, Manuel
Aguirre Cervás, Beatriz
Calvo Nieves, María Dolores
Bustamante, Rosa
Ganfornina Álvarez, María Dolores
Sánchez Romero, Diego
2014-09-19T16:17:35Z
2014-09-19T16:17:35Z
2013
International Journal of Colorectal Disease, 2013, p. 1-18
0179-1958
http://uvadoc.uva.es/handle/10324/6098
10.1007/s00384-012-1616-2
1
18
International Journal of Colorectal Disease
Producción Científica
Purpose Inverse correlations of apolipoprotein D (ApoD)
expression with tumor growth have been shown, therefore
proposing ApoD as a good prognostic marker for diverse
cancer types, including colorectal cancer (CRC). Besides,
ApoD expression is boosted upon oxidative stress (OS) in
many pathological situations. This study aims at understanding
the role of ApoD in the progression of human CRC.
Methods Samples of CRC and distant normal tissue (n051)
were assayed for levels of lipid peroxidation, expression
profile of OS-dependent genes, and protein expression.
Three single-nucleotide polymorphisms in the ApoD gene
were analyzed (n0139), with no significant associations
found. Finally, we assayed the effect of ApoD in proliferation
and apoptosis in the CRC HT-29 cell line.
application/pdf
eng
Springer-Verlag
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Colón - Cáncer - Tratamiento
Expression and potential role of apolipoprotein D on the death–survival balance of human colorectal cancer cells under oxidative stress conditions
info:eu-repo/semantics/article
SI