2024-03-29T10:37:17Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/62872021-06-23T09:48:42Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Córdova, Claudia
Gutiérrez, Beatriz
Martínez García, María del Carmen
Martín, Rubén
Gallego Muñoz, Patricia
Hernández Garrido, Marita
Nieto Salinas, María de la Paz
2014-09-26T16:07:08Z
2014-09-26T16:07:08Z
2014
PLos ONE, 2014, vol. 9, n. 4. p. 1-11
1932-6203
http://uvadoc.uva.es/handle/10324/6287
10.1371/journal.pone.0091282
1
4
11
PLoS ONE
9
Producción Científica
Pollen is the most common aeroallergen to cause seasonal conjunctivitis. The result of allergen exposure is a strong Th2-
mediated response along with conjunctival mast cell degranulation and eosinophilic infiltration. Oleanolic acid (OA) is
natural a triterpene that displays strong anti-inflammatory and immunomodulatory properties being an active anti-allergic
molecule on hypersensitivity reaction models. However, its effect on inflammatory ocular disorders including conjunctivits,
has not yet been addressed. Hence, using a Ragweed pollen (RWP)-specific allergic conjunctivitis (EAC) mouse model we
study here whether OA could modify responses associated to allergic processes. We found that OA treatment restricted
mast cell degranulation and infiltration of eosinophils in conjunctival tissue and decreased allergen-specific Igs levels in EAC
mice. Th2-type cytokines, secreted phospholipase A2 type-IIA (sPLA2-IIA), and chemokines levels were also significantly
diminished in the conjunctiva and serum of OA-treated EAC mice. Moreover, OA treatment also suppressed RWP-specific Tcell
proliferation. In vitro studies, on relevant cells of the allergic process, revealed that OA reduced the proliferative and
migratory response, as well as the synthesis of proinflammatory mediators on EoL-1 eosinophils and RBL-2H3 mast cells
exposed to allergic and/or crucial inflammatory stimuli such as RWP, sPLA2-IIA or eotaxin. Taken together, these findings
demonstrate the beneficial activity of OA in ocular allergic processes and may provide a new intervention strategy and
potential therapy for allergic diseases.
application/pdf
eng
Macau University of Science and Technology
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Conjuntivitis alérgica - Tratamiento
Oleanolic acid controls allergic and inflammatory responses in experimental allergic conjunctivitis
info:eu-repo/semantics/article
SI