2024-03-29T12:30:29Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/215952021-06-23T09:55:48Zcom_10324_1138com_10324_931com_10324_894col_10324_1226
Labrador Velandia, Sonia Cecilia
Alonso Alonso, María Luz
Álvarez Sánchez, Sara
González Zamora, Jorge
Pastor Jimeno, José Carlos
Fernández Bueno, Iván
Srivastava, Girish Kumar
2016
Producción Científica
Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using
MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases
application/pdf
http://uvadoc.uva.es/handle/10324/21595
eng
Baishideng Publishing Group
Células madre
Retina
Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials
info:eu-repo/semantics/article
TEXT
UVaDOC. Repositorio Documental de la Universidad de Valladolid
Hispana