2024-03-29T07:00:03Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/216832021-09-10T09:33:28Zcom_10324_1191com_10324_931com_10324_894col_10324_1379
UVaDOC
author
Álvarez González, Daniel
author
Gutiérrez Tobal, Gonzalo César
author
Campo Matias, Félix del
author
Hornero Sánchez, Roberto
2016-12-14T07:43:22Z
2016-12-14T07:43:22Z
2015
Expert Opinion on Therapeutic Patents, 2015, vol. 25:9,p. 971-989
1354-3776
http://uvadoc.uva.es/handle/10324/21683
10.1517/13543776.2015.1054094
Introduction. Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a major health problem with significant negative effects on the health and quality of life. Continuous positive airway pressure (CPAP) is currently the primary treatment option and it is considered the most effective therapy for OSAHS. Nevertheless, comfort issues due to improper fit to patient’s changing needs and breathing gas leakage limit the patient’s adherence to treatment.
Areas covered. The present patent review describes recent innovations in the treatment of OSAHS related to optimization of the positive pressure delivered to the patient, methods and systems for continuous self-adjusting pressure during inspiration and expiration phases, and techniques for electrical stimulation of nerves and muscles responsible for the airway patency.
Expert opinion. In the last years, CPAP-related inventions have mainly focused on obtaining an optimal self-adjusting pressure according to patient’s needs. Despite intensive research carried out, treatment compliance is still a major issue. Hypoglossal electrical nerve stimulation could be an effective secondary treatment option when CPAP primary therapy fails. Several patents have been granted focused on selective stimulation techniques and parameter optimization of the stimulating pulse waveform. Nevertheless, there remain important issues to address, like effectiveness and adverse events due to improper stimulation.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Airflow limitation
Positive airway pressure and electrical stimulation methods for obstructive sleep apnea treatment: a patent review (2005-2014)
info:eu-repo/semantics/article
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https://uvadoc.uva.es/bitstream/10324/21683/1/Alvarez_etal_2015_ExpertOpiniononTherapeuticPatents_post-review.pdf
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Alvarez_etal_2015_ExpertOpiniononTherapeuticPatents_post-review.pdf