2024-03-28T10:36:57Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/45742021-06-23T09:47:27Zcom_10324_1132com_10324_931com_10324_894col_10324_1205
UVaDOC
author
Gato Casado, Ángel Luis
author
Moro Balbás, José Antonio
author
Alonso Revuelta, María Isabel
author
Bueno i Torrens, David
author
Mano Bonín, Anibal de la
2014-04-03T08:16:32Z
2014-04-03T08:16:32Z
2005
The Anatomical record. Part A, 2005, p. 475-484
003-276X
http://uvadoc.uva.es/handle/10324/4574
10.1002/ar.a 20185
475
284 A
484
The anatomical record
284 A
Early in development, the behavior of neuroepithelial cells is controlled by several factors, which act in a developmentally regulated manner. Dif- fusible factors are secreted locally by the neuroepithelium itself, although other nearby structures may also be involved. Evidence suggests a physio- logical role for the cerebrospinal fluid in the development of the brain. Here, using organotypic cultures of chick embryo neuroepithelial explants from the mesencephalon, we show that the neuroepithelium in vitro is not able to self-induce cell survival, replication, and neurogenesis. We also show that the embryonic cerebrospinal fluid (E-CSF) promotes neuroepithelial stem cell survival and induces proliferation and neurogenesis in mesencephalic explants. These data strongly suggest that E-CSF is involved in the regu- lation of neuroepithelial cells behavior, supporting the hypothesis that this fluid plays a key role during the early development of the central nervous system.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Embriología
Líquido cefalorraquídeo
Neurología
Embryonic cerebrospinal fluid regulates neuroepithelial survival proliferation and neurogenesis in chick embryos
info:eu-repo/semantics/article
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https://uvadoc.uva.es/bitstream/10324/4574/1/Gato8.pdf
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ad92ad44313a125738d5c547a0733b0b
361002
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Gato8.pdf