2024-03-28T20:38:32Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/55402022-07-29T08:20:07Zcom_10324_1132com_10324_931com_10324_894col_10324_1205
UVaDOC
author
Moro Balbás, José Antonio
author
Carretero, José
author
Alonso Revuelta, María Isabel
author
Martín, C.
author
Gato Casado, Ángel Luis
author
Mano Bonín, Anibal de la
2014-07-22T10:38:48Z
2014-07-22T10:38:48Z
2008
Citokine, XXX, 2008
http://uvadoc.uva.es/handle/10324/5540
10.1016/j.cyto.2008.08.005
1
XXX
8
Citokine
XXX
It is known that interleukin 1b (IL-1b) and interleukin 6 (IL-6) are expressed post-natally in normal and
tumoral cells in the anterior pituitary, and that they play a role in both the liberation of different hormones
and in the growth, proliferation and tumor formation of the pituitary gland. However, their
expression and role during embryonic and fetal development remain unknown. We have performed an
immunocytochemistry study of prenatal expression and distribution of IL-1b and IL-6 in isolated embryonic
rat Rathke’s pouch prior to birth, more specifically between 13.5 and 19.5 days p.c. Western-blot
analysis carried out on 19.5-day p.c. embryos showed positive immunolabelling for IL-1b and IL-6. These
interleukins were initially expressed simultaneously in the rostral and ventral portions of Rathke’s pouch
in 15.5-day p.c. embryos, and this expression progressed caudodorsally in later developmental stages,
extending to most of the hypophysis before birth. The number of cells expressing these interleukins
increased throughout this period: 48.22% of anterior pituitary cells expressed IL-6 in 19.5-day embryos,
whilst IL-1b was positive in 39.8% of the cells. Moreover, we have demonstrated that some adenohypophyseal
cells co-express both interleukins. Such findings represent the first step towards an understanding
of the physiological role of these interleukins in anterior pituitary development.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Citoquímica
Hipófisis - Cáncer
Prenatal expression of interleukin 1B and interleukin 6 in the rat pituitary gland
info:eu-repo/semantics/article
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