2024-03-29T06:03:26Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/217302021-06-24T07:43:06Zcom_10324_1186com_10324_931com_10324_894com_10324_28542com_10324_952col_10324_1404col_10324_28543
Gioria, Estefanía
Martínez de Ilarduya Martínez de Ilarduya, Jesús María
Espinet Rubio, Pablo
2016-12-14T14:10:50Z
2016-12-14T14:10:50Z
2014
Organometallics, 2014, 33 (17), p. 4394–4400
0276-7333
http://uvadoc.uva.es/handle/10324/21730
10.1021/om5005379
17
Organometallics
A detailed study of the Negishi cross-coupling reaction of ArI (Ar = 2-C6H4CO2Et) and ZnEt2 with palladium catalysts containing conventional phosphines versus one using a chelating hybrid phosphine–electron-withdrawing olefin (P-EWO) ligand reveals that for conventional phosphines (e.g., PPh3) β-H elimination from intermediate [PdArEt(PPh3)2] is competitive with Ar–Et reductive elimination and is responsible for part of the undesired reduction product ArH. In contrast, with the EWO phosphine, the β-H elimination from intermediate [PdArEt(P-EWO)] is slow compared to the fast Ar–Et reductive elimination, and the undesired reduction product ArH observed proceeds in this case of hydrolysis of ZnArEt, formed in transmetalations where Ar is transferred from Pd to Zn. The rate of these transmetalations is comparable to the rate of reductive eliminations. Consequently, undesired transmetalations affording [PdEt2(P-EWO)] and ZnArEt are more effective at early stages of the reactions and less effective when the ethylating agent becomes poorer in ZnEt2 and richer in ZnEtX (X = I), as the reaction proceeds. Careful analysis of the experiments reveals the detailed changing evolution of the reaction, not only providing the main features of the catalytic cycle but also deducing how the reagents in the system change with time and what the effects on the products of these changes are.
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Chemistry
Experimental Study of the Mechanism of the Pd-catalyzed Aryl-alkyl Negishi Coupling using Hybrid Phosphine- Electron Withdrawing Olefin Ligands
info:eu-repo/semantics/article