2024-03-29T14:21:37Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/250552021-06-24T07:37:05Zcom_10324_32522com_10324_952com_10324_894com_10324_43677com_10324_954com_10324_1134com_10324_931col_10324_32524col_10324_43679col_10324_1214
Obeso Cáceres, Ana María de la Luz
Rocher Martín, María Asunción
López López, José Ramón
González, Constancio
2017-08-25T08:11:27Z
2017-08-25T08:11:27Z
1996
Zapata et al. (eds.). Frontiers in Arterial Chemoreception. New York, 1996, p.279-284.
http://uvadoc.uva.es/handle/10324/25055
10.1007/978-1-4615-5891-0_42
279
284
Frontiers in Arterial Chemoreception
The pívotal role of íntracellular free [Ca2+] fluctuatíons in the control of cellular functíons such as contraction and secretíon, íncludíng the release of neurotransmítters, was recognized many decades ago (see Rubín, 1982). More recently, the list of cellular functíons tríggered or modulated by the levels of Ca2+¡ has grown enormously. Addítional functíons regulated by [Ca2+)¡ include neuronal excítabílity, synaptic plastícíty, gene ex pressíon, cellular metabolísm, cell dívísíon and dífferentíatíon, and programmed cell dead (Míller, 1991; Clapham, 1995). Parallelíng the growth in this líst of Ca2+-controlled func tíons, a multíplicity of cellular mechanísms aimed at maintaining resting free [Ca2+)¡ in the range of l 00 nM for most cells has been described, allowing increases in Ca2+¡ levels that are specific in their magnitude, time course and spatial distributíon, accordíng to the cell function activated (Toescu, 1995).
Since Ca2+ cannot be metabolized, cells regulate theír cytoplasmic levels of free Ca2+ through numerous bínding proteíns and influx and efflux mechanisms (Fíg 1). Ca2+ ínflux to cell cytoplasm from the extracellular milieu occurs vía voltage or receptor operated channels or vía yet ill-defined capacítatíve pathways; the Na+/Ca 2+ exchanger can also produce in sorne círcumstances net ínflux of Ca2+ (Míller, 1991; Clapham, 1995). Ca2+ ef flux to the extracellular space occurs against electrochemical gradíents, and thereby the pumpíng out of Ca2+ is directly (Caz+ pump) or indirectly (Na+/Ca2+) coupled to the hy drolysis of ATP.
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Intracellular Ca2 + deposits and catecholamine secretion by chemoreceptor cells of the rabbit carotid body
info:eu-repo/semantics/bookPart