2024-03-28T15:27:43Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/384522021-06-24T07:43:46Zcom_10324_28542com_10324_952com_10324_894com_10324_1187com_10324_931col_10324_28543col_10324_1408
Chiral Bifunctional Thiosquaramides as Organocatalysts in the Synthesis of Enantioenriched 3,3-Disubstituted Oxindoles
Rodríguez Ferrer, Patricia
Naharro, Daniel
Maestro Fernández, Alicia
Andrés García, José María
Pedrosa Sáez, Rafael
Química orgánica
Producción Científica
Four novel chiral bifunctional thiosquaramides have been prepared from cyclopentyl dithiosquarates and diamines derived from natural l‐Valine and l‐tert‐Leucine. The novel thiosquaramides have been tested as organocatalyst in the nitro‐Michael addition of 3‐substituted oxindoles to different β‐aryl‐substituted nitroalkenes. The reaction occurred easily in high yields and excellent stereoselectivities, showing that the novel organocatalysts are much more effective than their thioureas and squaramides homologs.
2019-10-09T08:24:27Z
2019-10-09T08:24:27Z
2019
info:eu-repo/semantics/article
European Journal of Organic Chemistry 2019, 6539–6549
1434-193X
http://uvadoc.uva.es/handle/10324/38452
10.1002/ejoc.201901327
European Journal of Organic Chemistry
eng
https://onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201901327
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© Wiley
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Willey
SI