2024-03-29T05:51:39Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/68902022-07-29T08:21:24Zcom_10324_1134com_10324_931com_10324_894col_10324_1213
A chronic pain: inflammation-dependent chemoreceptor adaptation in rat carotid body
Liu, X.
He, Le
Dinger, Bruce
González, Constancio
Stensaas, L.
Fidone, Salvatore
Neurofisiología
Dolor crónico - Tratamiento
Producción Científica
Experiments in recent years have revealed labile electrophysiological and neurochemical
phenotypes in primary afferent neurons exposed to specific stimulus conditions associated with
the development of chronic pain. These studies collectively demonstrate that the mechanisms
responsible for functional plasticity are primarily mediated by novel neuroimmune interactions
involving circulating and resident immune cells and their secretory products, which together
induce hyperexcitability in the primary sensory neurons. In another peripheral sensory modality,
namely the arterial chemoreceptors, sustained stimulation in the form of chronic hypoxia (CH)
elicits increased chemoafferent excitability from the mammalian carotid body. Previous studies
which focused on functional changes in oxygen-sensitive type I cells in this organ have only
partially elucidated the molecular and cellular mechanisms which initiate and control this adaptive
response. Recent studies in our laboratory indicate a unique role for the immune system in
regulating the chemo-adaptive response of the carotid body to physiologically relevant levels of
hypoxia.
2014-11-04T09:39:49Z
2014-11-04T09:39:49Z
2011
info:eu-repo/semantics/article
Respiratry Physiology and Neurobiology : 2011, 178(3) 362-369
1569-9048
http://uvadoc.uva.es/handle/10324/6890
10.1016/j.resp.2011.03.006
362
178
369
Respiratory Physiology and Neurobiology
eng
https://www.sciencedirect.com/science/article/pii/S1569904811000887
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Elsevier
SI