2024-03-28T15:52:58Zhttp://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/45442021-06-23T09:47:23Zcom_10324_1132com_10324_931com_10324_894col_10324_1205
Alonso Revuelta, María Isabel
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500
0000-0001-8749-6755
Moro Balbás, José Antonio
6c9f08744407612b
500
0000-0002-4453-3760
Martín, C.
e46c5081-aecf-439f-9dab-6c9933209d6d
500
Mano Bonín, Anibal de la
f99d963a393564e9
500
Carnicero Gila, Estela María
8bad004b0346786b
500
0000-0002-9236-5503
Martínez Álvarez, C.
58a070e7-5b4a-4c11-9bb2-b83bc1179fde
500
Navarro, N.
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500
Cordero, J.
ed670312-e973-4021-8047-058a54e12058
500
Gato Casado, Ángel Luis
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500
0000-0002-3936-099X
2014-03-20T08:59:05Z
2014-03-20T08:59:05Z
2008
Cells Tissues Organs, April 2008, n.2. p.1-16
1422-6405
http://uvadoc.uva.es/handle/10324/4544
10.1159/000XXXXXX
1
2
16
Producción Científica
Previous studies have demonstrated that during neural fold fusion in different species, an apical extracellular material rich in glycoconjugates is involved. However, the composi- tion and the biological role of this material remain undeter- mined. In this paper, we show that this extracellular matrix in rat increases notably prior to contact between the neural folds, suggesting the dynamic behaviour of the secretory process. Immunostaining has allowed us to demonstrate that this extracellular matrix contains chondroitin sulphate proteoglycan (CSPG), with a spatio-temporal distribution pattern, suggesting a direct relationship with the process of adhesion. The degree of CSPG involvement in cephalic neu- ral fold fusion in rat embryos was determined by treatment with specific glycosidases. In vitro rat embryo culture and microinjection techniques were employed to carry out se- lective digestion, with chondroitinase AC, of the CSPG on the apical surface of the neural folds; this was done immediately prior to the bonding of the cephalic neural folds. In all the treated embryos, cephalic defects of neural fold fusion could
tant role in the fusion of the cephalic neural folds in rat em- bryos, which implies that this proteoglycan could be in- volved in cellular recognition and adhesion.
Abbreviations used in this paper
CSPG chondroitin sulphate proteoglycan
HSPG heparan sulphate proteoglycan
PBS phosphate-buffered saline
SEM scanning electron microscopy
be detected. These results show that CSPG plays an impor-
application/pdf
eng
Karger
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Tubo neural - obstrucción
Embriología animal
Chondroitin sulphate mediated fusion of brain: neural folds in rat embryons
info:eu-repo/semantics/article
SI
ORIGINAL
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oai:uvadoc.uva.es:10324/4544
2021-06-23 11:47:23.691
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