RT info:eu-repo/semantics/article
T1 Neural Network Reorganization Analysis During an Auditory Oddball Task in Schizophrenia Using Wavelet Entropy
A1 Gómez Pilar, Javier
A1 Poza Crespo, Jesús
A1 Bachiller Matarranz, Alejandro
A1 Gómez Peña, Carlos
A1 Molina Rodríguez, Vicente
A1 Hornero Sánchez, Roberto
K1 wavelet entropy
AB The aim of the present study was to characterize the neural networkreorganization during a cognitive task in schizophrenia (SCH) by means of waveletentropy (WE). Previous studies suggest that the cognitive impairment in patients with SCHcould be related to the disrupted integrative functions of neural circuits. Nevertheless,further characterization of this effect is needed, especially in the time-frequency domain.This characterization is sensitive to fast neuronal dynamics and their synchronization thatmay be an important component of distributed neuronal interactions; especially in light ofthe disconnection hypothesis for SCH and its electrophysiological correlates. In this work,the irregularity dynamics elicited by an auditory oddball paradigm were analyzed throughsynchronized-averaging (SA) and single-trial (ST) analyses. They provide complementaryinformation on the spatial patterns involved in the neural network reorganization. Ourresults from 20 healthy controls and 20 SCH patients showed a WE decrease from baselineto response both in controls and SCH subjects. These changes were significantly more pronounced for healthy controls after ST analysis, mainly in central and frontopolar areas.On the other hand, SA analysis showed more widespread spatial differences than STresults. These findings suggest that the activation response is weakly phase-locked tostimulus onset in SCH and related to the default mode and salience networks. Furthermore,the less pronounced changes in WE from baseline to response for SCH patients suggest animpaired ability to reorganize neural dynamics during an oddball task.
PB MDPI
SN 1099-4300
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/21555
UL http://uvadoc.uva.es/handle/10324/21555
LA eng
NO Entropy 2015, 17, p. 5241-5256
NO Producción Científica
DS UVaDOC
RD 19-sep-2024