RT info:eu-repo/semantics/article
T1 Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system.
A1 Inostroza Brito, Karla E.
A1 Collin, Estelle
A1 Siton Mendelson, Orit
A1 Smith, Katherine H.
A1 Monge Marcet, Amália
A1 Ferreira, Daniela S.
A1 Pérez Rodríguez, Raúl
A1 Alonso Rodrigo, Matilde
A1 Rodríguez Cabello, José Carlos
A1 Reis, Rui Luís
A1 Sagués, Francesc
A1 Botto, Lorenzo
A1 Bitton, Ronit
A1 Azevedo, Helena S.
A1 Mata, Álvaro
K1 Moléculas - Propiedades
AB Controlling molecular interactions between bioinspired molecules can enable the development of new materials with higher complexity and innovative properties. Here we report on a dynamic system that emerges from the conformational modification of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be maintained in, non- equilibrium for substantial periods of time. The system enables the formation of a  robust  membrane  that  displays controlled assembly and disassembly capabilities, adhesion and sealing to surfaces, self-healing  and  the  capability  to undergo morphogenesis into tubular structures with high spatiotemporal control. We use advanced microscopy along with turbidity and spectroscopic measurements to investigate the mechanism of assembly and its relation to the distinctive membrane architecture and the resulting dynamic properties. Using cell-culture experiments with endothelial and adipose- derived stem cells, we demonstrate the potential of this system to generate complex bioactive scaffolds for applications such as tissue engineering.
PB Nature Publishing Group
SN ISSN: 1755-4330
YR 2015
FD 2015
LK http://uvadoc.uva.es/handle/10324/21846
UL http://uvadoc.uva.es/handle/10324/21846
LA spa
NO Nature Chemistry, 2015, vol. 7, p. 897–904
NO Producción Científica
DS UVaDOC
RD 24-abr-2024