RT info:eu-repo/semantics/article T1 Continuous wavelet transform in the study of the time-scale properties of intracranial pressure in hydrocephalus A1 García, María A1 Poza Crespo, Jesús A1 Santamarta Gómez, David A1 Romero Oraa, Roberto A1 Hornero Sánchez, Roberto AB Normal pressure hydrocephalus (NPH) encompasses a heterogeneous group of disorders generallycharacterised by clinical symptoms, ventriculomegaly and anomalous cerebrospinal fluid (CSF)dynamics. Lumbar infusion tests (ITs) are frequently performed in the preoperatory evaluation ofpatients who show NPH features. The analysis of intracranial pressure (ICP) signals recorded duringITs could be useful to better understand the pathophysiology underlying NPH and to assist treatmentdecisions. In this study, 131 ICP signals recorded during ITs were analysed using two continuous wavelet transform (CWT)-derived parameters: Jensen Divergence (JD) and Spectral Flux (SF). Theseparameters were studied in two frequency bands, associated with different components of the signal:𝐵"(0.15 - 0.3 Hz), related to respiratory blood pressure oscillations; and 𝐵# (0.67 - 2.5 Hz), related toICP pulse waves. Statistically significant differences (𝑝 < 1.70 ∙ 10+,, Bonferroni-corrected Wilcoxonsigned rank tests) in pairwise comparisons between phases of ITs were found using the mean andstandard deviation of JD and SF. These differences were mainly found in 𝐵#, where a lowerirregularity and variability, together with less prominent time-frequency fluctuations, were found inthe hypertension phase of ITs. Our results suggest that wavelet analysis could be useful forunderstanding CSF dynamics in NPH. PB The Royal Society Publishing YR 2018 FD 2018 LK http://uvadoc.uva.es/handle/10324/31347 UL http://uvadoc.uva.es/handle/10324/31347 LA eng NO Philosophical Transactions of The Royal Society A-Mathematical Physical and Engineering Sciences, vol. 376 (2126), pp. 20170251 NO Producción Científica DS UVaDOC RD 19-sep-2024