RT info:eu-repo/semantics/article
T1 Alterations of Effective Connectivity Patterns in Mild Cognitive Impairment: An MEG Study
A1 Gómez Peña, Carlos
A1 Juan Cruz, Celia
A1 Poza Crespo, Jesús
A1 Ruiz Gómez, Saúl José
A1 Gómez Pilar, Javier
A1 Núñez Novo, Pablo
A1 García Gadañón, María
A1 Fernández, Alberto
A1 Hornero Sánchez, Roberto
AB Neuroimaging techniques have demonstrated over the years their ability tocharacterize the brain abnormalities associated with different neurodegenerative diseases.Among all these techniques, magnetoencephalography (MEG) stands out by its high temporalresolution and noninvasiveness. The aim of the present study is to explore the couplingpatterns of resting-state MEG activity in subjects with mild cognitive impairment (MCI). Toachieve this goal, five minutes of spontaneous MEG activity were acquired with a 148-channel whole-head magnetometer from 18 MCI patients and 26 healthy controls. Interchannelrelationships were investigated by means of two complementary coupling measures:coherence and Granger causality. Coherence is a classical method of functional connectivity,while Granger causality quantifies effective (or causal) connectivity. Both measures werecalculated in the five conventional frequency bands: delta (d, 1-4 Hz), theta (q, 4-8 Hz), alpha(a, 8-13 Hz), beta (b, 13-30 Hz), and gamma (g, 30-45Hz). Our results showed thatconnectivity values were lower for MCI patients than for controls in all frequency bands.However, only Granger causality revealed statistically significant differences between groups(p-values < 0.05, FDR corrected Mann-Whitney U-test), mainly in the beta band. Our resultssupport the role of MCI as a disconnection syndrome, which elicits early alterations ineffective connectivity patterns. These findings can be helpful to identify the neural substratesinvolved in prodromal stages of dementia.
PB IOS Press
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/31350
UL http://uvadoc.uva.es/handle/10324/31350
LA eng
NO Journal of Alzheimers Disease, In Press
NO Producción Científica
DS UVaDOC
RD 23-abr-2024