RT info:eu-repo/semantics/bachelorThesis
T1 Bioaerogels: Promising materials for impregnation of drugs
A1 Rodríguez Antolín, Jorge
A2 Universidad de Valladolid. Escuela de Ingenierías Industriales
K1 Bioaerogels
K1 Polysaccharides
K1 Supercritical impregnation
K1 Diffusion method
K1 Esomeprazole
K1 3302 Tecnología Bioquímica
AB The following work examines the possibility of impregnating chosen model drug intobioaerogels to obtain final formulation with added value. The drug used in this study wasesomeprazole, used to treat acid-related diseases.In the first part of the work, bioaerogels were prepared. Polysaccharide aerogels arelightweight biocompatible and biodegradable materials, suitable for applications inpharmaceutical industry. For this purpose, three different cores were prepared: pectin,alginate and their mixture, followed by coating with chitosan layer. The production of thebioaerogels follows a sol-gel synthesis and supercritical drying technique. All sampleswere characterised, and optimisation was performed based on examined properties.Aerogels having a pectin core and chitosan coating showed the highest surface area andthe highest adsorption capacity.In the second part, the impregnation of esomeprazole was performed using two differentmethods: supercritical impregnation and diffusion via sol-gel synthesis. For supercriticalimpregnation, supercritical carbon dioxide was used as a solvent for impregnation of thedrug. In the diffusion method, the model drug was added during sol-gel synthesis usingethanol as solvent. Finally, complete characterisation of prepared formulation followedby drug release studies was performed.The study showed successful impregnation of esomeprazole using either carbon dioxideor ethanol as a solvent. Bioaerogels proved to be promising as carriers for achieving theoptimal release of the chosen drug
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/41412
UL http://uvadoc.uva.es/handle/10324/41412
LA eng
NO Departamento de Ingeniería Química y Tecnología del Medio Ambiente
DS UVaDOC
RD 27-abr-2024