RT info:eu-repo/semantics/article
T1 The overlooked immune state in candidemia: A risk factor for mortality
A1 Ortega Loubon, Christian Joseph
A1 Cano Hernández, Beatriz
A1 Poves Álvarez, Rodrigo
A1 Muñoz Moreno, María Fe
A1 Román García, Patricia
A1 Balbás Álvarez, Sara
A1 Varga Martínez, Olga de la
A1 Gómez Sánchez, Esther
A1 Gómez Pesquera, Estefanía
A1 Lorenzo López, Mario
A1 Tamayo Gómez, Eduardo
A1 Heredia Rodríguez, María
K1 Lymphopenia
K1 Linfopenia
K1 Candidemia
K1 Mortality
K1 Mortalidad
K1 Prognosis
K1 Pronóstico
K1 Immunosuppression
K1 Inmunosupresión
AB Lymphopenia has been related to increased mortality in septic patients. Nonetheless, the impact of lymphocyte count on candidemia mortality and prognosis has not been addressed. We conducted a retrospective study, including all admitted patients with candidemia from 2007 to 2016. We examined lymphocyte counts during the first 5 days following the diagnosis of candidemia. Multivariable logistic regression analysis was performed to determine the relationship between lymphocyte count and mortality. Classification and Regression Tree analysis was used to identify the best cut-off of lymphocyte count for mortality associated with candidemia. From 296 cases of candidemia, 115 died, (39.8% 30-day mortality). Low lymphocyte count was related to mortality and poor outcome (p < 0.001). Lymphocyte counts <0.703 × 109 cells/L at diagnosis (area under the curve (AUC)-ROC, 0.783 ± 0.042; 95% confidence interval (CI), 0.700–0.867, p < 0.001), and lymphocyte count <1.272 × 109 cells/L five days later (AUC-ROC, 0.791 ± 0.038; 95%CI, 0.716–0.866, p < 0.001) increased the odds of mortality five-fold (odds ratio (OR), 5.01; 95%CI, 2.39–10.93) at time of diagnosis, and three-fold (OR, 3.27; 95%CI, 1.24–8.62) by day 5, respectively. Low lymphocyte count is an independent predictor of mortality in patients with candidemia and might serve as a biomarker for predicting candidemia-associated mortality and poor outcome.
PB MDPI
SN 2077-0383
YR 2019
FD 2019
LK http://uvadoc.uva.es/handle/10324/45473
UL http://uvadoc.uva.es/handle/10324/45473
LA eng
NO Journal of Clinical Medicine, 2019, vol. 8, n. 10. 12 p.
NO Producción Científica
DS UVaDOC
RD 01-may-2024