RT info:eu-repo/semantics/article
T1 Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients
A1 Almansa Mora, Raquel
A1 Martín, Silvia
A1 Martín Fernández, Marta
A1 Heredia Rodríguez, María
A1 Gómez Sánchez, Esther
A1 Aragón, Marta
A1 Andrés Iglesias, Cristina
A1 Calvo, Dolores
A1 Rico Feijoo, Jesús
A1 Esteban Velasco, María Carmen
A1 Vaquero Roncero, Luis Mario
A1 Ortega, Alicia
A1 Gómez Pesquera, Estefanía
A1 Lorenzo López, Mario
A1 López de Cenarruzabeitia, Íñigo
A1 Benavides, Diana
A1 López Sánchez, Jaime
A1 Doncel, Cristina
A1 González Sánchez, Carmen
A1 Zarca, Esther
A1 Ríos Llorente, Alberto
A1 Díaz, Agustín
A1 Sánchez Barrado, Elisa
A1 Beltrán de Heredia Rentería, Juan
A1 Calvo Vecino, José María
A1 Muñoz Bellvís, Luis
A1 Gómez Herreras, José Ignacio
A1 Aldecoa Álvarez Santullano, César Enrique
A1 Tamayo Gómez, Eduardo
A1 Bermejo Martín, Jesús Francisco
K1 Procalcitonin
K1 Procalcitonina
K1 HLA-DR
K1 Sepsis
K1 3213 Cirugía
AB Early recognition of sepsis is a key factor to improve survival to this disease in surgical patients, since itallows prompt control of the infectious source. Combining pro-infammatory and immunosupressionbiomarkers could represent a good strategy to improve sepsis detection. Here we evaluated thecombination of procalcitonin (PCT) with gene expression levels of HLA-DRA to detect sepsis in acohort of 154 surgical patients (101 with sepsis and 53 with no infection). HLA-DRA expression wasquantifed using droplet digital PCR, a next-generation PCR technology. Area under the receiveroperating curve analysis (AUROC) showed that the PCT/HLA-DRA ratio outperformed PCT to detectsepsis (AUROC [CI95%], p): PCT: 0.80 [0.73–0.88], <0.001; PCT/HLA-DRA: 0.85 [0.78–0.91], <0.001. Inthe multivariate analysis, the ratio showed a superior ability to predict sepsis compared to that of PCT(OR [CI 95%], p): PCT/HLA-DRA: 7.66 [1.82–32.29], 0.006; PCT: 4.21 [1.15–15.43] 0.030. Multivariateanalysis was confrmed using a new surgical cohort with 74 sepsis patients and 21 controls: PCT/HLADRA:34.86 [1.22–995.08], 0.038; PCT: 5.52 [0.40–75.78], 0.201. In conclusion, the combination of PCTwith HLA-DRA is a promising strategy for improving sepsis detection in surgical patients.
PB Springer Nature
SN 2045-2322
YR 2018
FD 2018
LK http://uvadoc.uva.es/handle/10324/45485
UL http://uvadoc.uva.es/handle/10324/45485
LA eng
NO Scientific Reports, 2018, vol. 8. 9 p.
NO Producción Científica
DS UVaDOC
RD 27-abr-2024