RT info:eu-repo/semantics/article
T1 Expression and potential role of apolipoprotein D on the death–survival balance of human colorectal cancer cells under oxidative stress conditions
A1 Bajo Grañeras, Raquel
A1 Crespo Sanjuan, Jesús
A1 García Centeno, Rosa María
A1 Garrote Adrados, José Antonio
A1 Gutiérrez, Gabriel
A1 García Tejeiro, Manuel
A1 Aguirre Cervás, Beatriz
A1 Calvo Nieves, María Dolores
A1 Bustamante, Rosa
A1 Ganfornina Álvarez, María Dolores
A1 Sánchez Romero, Diego
K1 Colón - Cáncer - Tratamiento
AB Purpose Inverse correlations of apolipoprotein D (ApoD)expression with tumor growth have been shown, thereforeproposing ApoD as a good prognostic marker for diversecancer types, including colorectal cancer (CRC). Besides,ApoD expression is boosted upon oxidative stress (OS) inmany pathological situations. This study aims at understandingthe role of ApoD in the progression of human CRC.Methods Samples of CRC and distant normal tissue (n051)were assayed for levels of lipid peroxidation, expressionprofile of OS-dependent genes, and protein expression.Three single-nucleotide polymorphisms in the ApoD genewere analyzed (n0139), with no significant associationsfound. Finally, we assayed the effect of ApoD in proliferationand apoptosis in the CRC HT-29 cell line.
PB Springer-Verlag
SN 0179-1958
YR 2013
FD 2013
LK http://uvadoc.uva.es/handle/10324/6098
UL http://uvadoc.uva.es/handle/10324/6098
LA eng
NO International Journal of Colorectal Disease, 2013, p. 1-18
NO Producción Científica
DS UVaDOC
RD 20-abr-2024