RT info:eu-repo/semantics/article
T1 Molecular mechanisms involved in hypoxia-induced alterations in bone remodeling
A1 Usategui Martín, Ricardo
A1 Rigual Bonastre, Ricardo Jaime
A1 Ruiz Mambrilla, Marta María
A1 Fernández Gómez, José María Fidel
A1 Dueñas Laita, Antonio
A1 Pérez Castrillon, José Luis
K1 Hypoxia
K1 Hipoxia
K1 Bone remodeling
K1 Bone health
K1 Huesos - Regeneración
K1 Bones - Metabolism - Disorders
K1 Huesos - Metabolismo, trastornos del
K1 Hypoxia Inducible Factor (HIF)
K1 Osteoclast
K1 Osteoblast
K1 Oxygen
K1 Oxígeno
K1 Cell Biology
K1 Medicine
K1 2407 Biología Celular
K1 32 Ciencias Médicas
AB Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and physiological bone functions sufficient oxygen is required, as evidence has shown that hypoxia may influence bone health. In this scenario, this review aimed to analyze the molecular mechanisms involved in hypoxia-induced bone remodeling alterations and their possible clinical consequences. Hypoxia has been associated with reduced bone formation and reduced osteoblast matrix mineralization due to the hypoxia environment inhibiting osteoblast differentiation. A hypoxic environment is involved with increased osteoclastogenesis and increased bone resorptive capacity of the osteoclasts. Clinical studies, although with contradictory results, have shown that hypoxia can modify bone remodeling.
PB MDPI
SN 1422-0067
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/62384
UL https://uvadoc.uva.es/handle/10324/62384
LA eng
NO International Journal of Molecular Sciences, 2022, Vol. 23, Nº. 6, 3233
NO Producción Científica
DS UVaDOC
RD 17-may-2024