RT info:eu-repo/semantics/article T1 Scleral changes induced by atropine in chicks as an experimental model of myopia A1 Gallego Muñoz, Patricia A1 Martínez García, María del Carmen A1 Pérez Merino, Pablo A1 Ibares Frías, Lucía A1 Mayo Iscar, Agustín A1 Merayo Lloves, Jesús K1 Miopia - Tratamiento AB Purpose: To determine the effects of intravitreal atropine on scleral growth in theform-deprived chick as an experimental model of myopia.Methods: Five groups of five chicks were studied from day 0–12 post-hatching.One group remained untreated (C), and four were form-deprived by monocularlight diffusers to induce myopia. Two groups (RL and A) wore diffusers for9 days, and the other two groups (D and D + A) wore diffusers throughout thestudy. Group D received no further treatment (myopia positive control). GroupsA and D + A received intravitreal injections of atropine for days 9–12. Measurementsof refractive error and axial length were performed on days 0, 9, and 12.Sclera changes were assessed in cartilaginous and fibrous layers by histologicalanalysis.Results: All form-deprived eyes had a myopic refractive error on day 9. All atropine-treated groups were hyperopic on day 12. The effect of atropine was mostevident in Group D + A in which diffusers were maintained throughout treatmentand changes in refractive error were statistically significant. The observedchanges in axial length were in line with the changes in refractive error. The scleralfibrous layer thickness increased, and the sceral cartilaginous layer underwent aslight thinning compared to Group D, the myopia positive control.Conclusions: If the signals that induce growth remain during atropine treatment,morphological changes in sclera are produced: the scleral fibrous layer thickened,and the sceral cartilaginous layer thinned. These changes resulted in refractiveerror recovery, and the ocular growth was stopped. The data suggested the atropinewas acting throughout the scleral fibrous layer. PB The College of Optometrists SN 0275-5408 YR 2012 FD 2012 LK http://uvadoc.uva.es/handle/10324/6288 UL http://uvadoc.uva.es/handle/10324/6288 LA eng NO Ophtalmic and Physiological Optics, 2012, vol. 32, p. 478-484 NO Producción Científica DS UVaDOC RD 19-sep-2024