RT info:eu-repo/semantics/article
T1 Mitochondrial ion channels in pancreatic β‐cells: Novel pharmacological targets for the treatment of Type 2 diabetes
A1 De Marchi, Umberto
A1 Fernandez‐Martinez, Silvia
A1 de la Fuente, Sergio
A1 Wiederkehr, Andreas
A1 Santo‐Domingo, Jaime
K1 mitochondria, ion channels, MCU, calcium, diabetes
AB Pancreatic beta-cells are central regulators of glucose homeostasis. By tightly coupling nutrient sensing and granule exocytosis, beta-cells adjust the secretion of insulin to the circulating blood glucose levels. Failure of beta-cells to augment insulin secretion in insulin-resistant individuals leads progressively to impaired glucose tolerance, Type 2 diabetes, and diabetes-related diseases. Mitochondria play a crucial role in β-cells during nutrient stimulation, linking the metabolism of glucose and other secretagogues to the generation of signals that promote insulin secretion. Mitochondria are double-membrane organelles containing numerous channels allowing the transport of ions across both membranes. These channels regulate mitochondrial energy production, signaling, and cell death. The mitochondria of β-cells express ion channels whose physio/pathological role is underappreciated. Here, we describe the mitochondrial ion channels identified in pancreatic β-cells, we further discuss the possibility of targeting specific β-cell mitochondrial channels for the treatment of Type 2 diabetes, and we finally highlight the evidence from clinical studies.
PB Wiley
SN 0007-1188
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/66020
UL https://uvadoc.uva.es/handle/10324/66020
LA spa
NO Br J Pharmacol. May 2021. vol. 178, n. 10, p. 2077-2095.
NO Producción Científica
DS UVaDOC
RD 03-jun-2024