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dc.contributor.authorMielgo Ayuso, Juan Francisco 
dc.contributor.authorPietrantonio, Laura
dc.contributor.authorViribay, Aitor
dc.contributor.authorCalleja González, Julio
dc.contributor.authorGonzález Bernal, Jerónimo J.
dc.contributor.authorFernández Lázaro, Diego 
dc.date.accessioned2023-04-19T08:02:42Z
dc.date.available2023-04-19T08:02:42Z
dc.date.issued2021
dc.identifier.citationNutrients, 2021, Vol. 13, Nº. 12, 4359es
dc.identifier.issn2072-6643es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/59203
dc.descriptionProducción Científicaes
dc.description.abstractL-Carnitine (L-C) and any of its forms (glycine-propionyl L-Carnitine (GPL-C) or L-Carnitine L-tartrate (L-CLT)) has been frequently recommended as a supplement to improve sports performance due to, among others, its role in fat metabolism and in maintaining the mitochondrial acetyl-CoA/CoA ratio. The main aim of the present systematic review was to determine the effects of oral L-C supplementation on moderate- (50–79% V˙O2 max) and high-intensity (≥80% V˙O2 max) exercise performance and to show the effective doses and ideal timing of its intake. A structured search was performed according to the PRISMA® statement and the PICOS guidelines in the Web of Science (WOS) and Scopus databases, including selected data obtained up to 24 October 2021. The search included studies where L-C or glycine-propionyl L-Carnitine (GPL-C) supplementation was compared with a placebo in an identical situation and tested its effects on high and/or low–moderate performance. The trials that used the supplementation of L-C together with additional supplements were eliminated. There were no applied filters on physical fitness level, race, or age of the participants. The methodological quality of studies was evaluated by the McMaster Critical Review Form. Of the 220 articles obtained, 11 were finally included in this systematic review. Six studies used L-C, while three studies used L-CLT, and two others combined the molecule propionyl L-Carnitine (PL-C) with GPL-C. Five studies analyzed chronic supplementation (4–24 weeks) and six studies used an acute administration (<7 days). The administration doses in this chronic supplementation varied from 1 to 3 g/day; in acute supplementation, oral L-C supplementation doses ranged from 3 to 4 g. On the one hand, the effects of oral L-C supplementation on high-intensity exercise performance variables were analyzed in nine studies. Four of them measured the effects of chronic supplementation (lower rating of perceived exertion (RPE) after 30 min at 80% V˙O2 max on cycle ergometer and higher work capacity in “all-out” tests, peak power in a Wingate test, and the number of repetitions and volume lifted in leg press exercises), and five studies analyzed the effects of acute supplementation (lower RPE after graded exercise test on the treadmill until exhaustion and higher peak and average power in the Wingate cycle ergometer test). On the other hand, the effects of L-C supplementation on moderate exercise performance variables were observed in six studies. Out of those, three measured the effect of an acute supplementation, and three described the effect of a chronic supplementation, but no significant improvements on performance were found. In summary, L-C supplementation with 3 to 4 g ingested between 60 and 90 min before testing or 2 to 2.72 g/day for 9 to 24 weeks improved high-intensity exercise performance. However, chronic or acute L-C or GPL-C supplementation did not present improvements on moderate exercise performance.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLipids - Oxidationes
dc.subjectSports medicinees
dc.subjectDeportees
dc.subjectNutritiones
dc.subjectDietary supplements - Therapeutic usees
dc.subject.classificationAerobic performancees
dc.subject.classificationAnaerobic performancees
dc.subject.classificationRecoveryes
dc.titleEffect of acute and chronic oral L-carnitine supplementation on exercise performance based on the exercise intensity: A systematic reviewes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2021 The authorses
dc.identifier.doi10.3390/nu13124359es
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/13/12/4359es
dc.identifier.publicationfirstpage4359es
dc.identifier.publicationissue12es
dc.identifier.publicationtitleNutrientses
dc.identifier.publicationvolume13es
dc.peerreviewedSIes
dc.identifier.essn2072-6643es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco3104.06 Nutriciónes
dc.subject.unesco3209 Farmacologíaes


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