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dc.contributor.author | García-Sancho Martín, Francisco Javier | |
dc.date.accessioned | 2014-09-30T17:17:39Z | |
dc.date.available | 2015-09-30T23:40:08Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Journal of Physiology, 2014, p. 261-268 | es |
dc.identifier.issn | 0022-3751 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/6348 | |
dc.description | Producción Científica | es |
dc.description.abstract | Cross-talk between organelles and plasma membrane Ca2+ channels is essential for modulation of the cytosolic Ca2+ ([Ca2+]C) signals, but such modulation may differ among cells. In chromaffin cells Ca2+ entry through voltage-operated channels induces calcium release from the endoplasmic reticulum (ER) that amplifies the signal. [Ca2+]C microdomains as high as 20–50 μM are sensed by subplasmalemmal mitochondria, which accumulate large amounts of Ca2+ through the mitochondrial Ca2+ uniporter (MCU). Mitochondria confine the high-Ca2+ microdomains (HCMDs) to beneath the plasma membrane,where exocytosis of secretory vesicles happens. Cell core [Ca2+]C is much smaller (1–2 μM). By acting as a Ca2+ sink, mitochondria stabilise theHCMDin space and time. In non-excitableHEK293 cells, activation of store-operated Ca2+ entry, triggered by ERCa2+ emptying, also generated subplasmalemmal HCMDs, but, in this case, most of the Ca2+ was taken up by the ER rather than bymitochondria. The smaller size of the [Ca2+]C peak in this case (about 2 μM)may contribute to this outcome, as the sarco-endoplasmic reticulum Ca2+ ATPase has much higher Ca2+ affinity than MCU. It is also possible that the relative positioning of organelles, channels and effectors, as well as cytoskeleton and accessory proteins plays an important role. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | The Physiological Society | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Calcio - Absorción | es |
dc.title | The coupling of plasma membrane calcium entry to calcium uptake by endoplasmic reticulum and mitochondria | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1113/jphysiol.2013.255661 | es |
dc.identifier.publicationfirstpage | 261 | es |
dc.identifier.publicationlastpage | 268 | es |
dc.identifier.publicationtitle | Journal of Physiology | es |
dc.peerreviewed | SI | es |
dc.description.embargo | 2015-09-30 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
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