RT info:eu-repo/semantics/conferenceObject
T1 Bispectral Analysis of Spontaneous EEG Activity from Patients with Moderate Dementia Due to Alzheimer’s Disease
A1 Gómez Peña, Carlos
A1 Vaquerizo Villar, Fernando
A1 Poza Crespo, Jesús
A1 Ruiz Gómez, Saúl José
A1 Tola Arribas, Miguel Ángel
A1 Cano, Mónica
A1 Hornero Sánchez, Roberto
AB Dementia due to Alzheimer’s disease (AD) is acommon disorder with a great impact on the patients’ qualityof life. The aim of this pilot study was to characterizespontaneous electroencephalography (EEG) activity indementia due to AD using bispectral analysis. Five minutes ofEEG activity were recorded from 17 patients with moderatedementia due to AD and 19 age-matched controls. Bispectrumresults revealed that AD patients are characterized by anincrease of phase coupling at low frequencies in comparisonwith controls. Additionally, some bispectral features calculatedfrom the bispectrum showed significant differences betweenboth groups (p < 0.05, Mann-Whitney U test with Bonferroni’scorrection). Finally, a stepwise logistic regression analysis witha leave-one-out cross-validation procedure was used forclassification purposes. An accuracy of 86.11% (sensitivity =88.24%; specificity =84.21%) was achieved. This study suggeststhe usefulness of bispectral analysis to provide further insightsinto the underlying brain dynamics associated with AD
SN 978-1-5090-2809-2
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/31352
UL http://uvadoc.uva.es/handle/10324/31352
LA eng
NO Producción Científica
DS UVaDOC
RD 28-abr-2024