RT info:eu-repo/semantics/article T1 Involvement of sulfated proteoglycans in embryonic brain expansion at earliest stages of development in rat embryos A1 Alonso Revuelta, María Isabel A1 Gato Casado, Ángel Luis A1 Moro Balbás, José Antonio A1 Martina, P. A1 Barbosa Ayucar, Enrique K1 Embriología K1 Cerebro - Enfermedades AB The expansive force generated by the positive pressure of the neural tube fluid confined inside the brain vesicles has been shown to be a key factor during the earliest stages of brain morphogP.nesis and development of chick embryos. In a previous study,we demonstrated the existence of an intracavity extracellular matrix rich in condroitin sulfate in this species, which could be in­ volved in the regulation of the expa nsive process. In this report, scanning electron microscopy and immunohisto­ chemistry show that,after neurulation,a similar extracel­ lular matrix rich in chondroitin sulfate is present inside the brain vesicles of rat embryos during early enlarge­ ment of the brain anlage. In vitro treatment of rat embryos-Abbreviations used in this paper bryos with B-0-xyloside (a chemical compound which PB Karger YR 1999 FD 1999 LK http://uvadoc.uva.es/handle/10324/4631 UL http://uvadoc.uva.es/handle/10324/4631 LA eng NO Cell Tissues Organs, 1999, vol. 165, p.1-9 NO Producción Científica DS UVaDOC RD 27-abr-2024