RT info:eu-repo/semantics/doctoralThesis
T1 Enfermedad multi-valvular y eje renina-angiotensina-aldosterona en la era de las terapias valvulares a través de catéter.
A1 Catalá Ruiz, Pablo
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Corazón - Válvulas - Enfermedad
K1 Cardiac remodellng
K1 Remodelado cardiaco
K1 Multivalvular
K1 32 Ciencias Médicas
AB The PhD thesis analyze several factors that may modify the prognosis in patients with valve disease. First of all, factors related to mitral regurgitation are evaluated in patients receiving a transcatheter aortic valve replacement (TAVR). A prospective validation of a score that predicts mitral regurgitation persistence after TAVR is performed. This score will help to plan the best treatment for these patients.  Second, an analysis of the effect of renin-angiontensin system inhibitors (RASI) on patients with aortic stenosis after TAVR is done. The evaluated outcomes are the total mortality, the cardiovascular mortality  and its effects on cardiac remolding. This study suggests that RASI may improve these outcomes in patients after TAVR. Finally, a subgroup analysis of patients with multi-valvular disease is performed. Patients with aortic stenosis and significant mitral or tricuspid regurgitation are included. RASI effects are evaluated in this sub-group of patients. Less  improvement is observed compared to the global population with aortic stenosis. These worse outcomes may be related to a more advanced stage of the valvular disease and an adverse cardiac remodeling. In this scenario, RASI may no modify the evolution of the disease.
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/61079
UL https://uvadoc.uva.es/handle/10324/61079
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 01-jun-2024