RT info:eu-repo/semantics/bookPart
T1 Human intestinal dendritic cell and macrophage subsets in coeliac disease
A1 Arranz Sanz, Eduardo
A1 de Prado, Angel
A1 Fiz López, Aida
A1 Arribas, Elisa
A1 Garrote Adrados, José Antonio
A1 Bernardo, David
K1 Inmunología
K1 Inmunología Humana
K1 Inmunopatología
K1 Enfermedad Celíaca
K1 Células Dendríticas
K1 Inmunología de las Mucosas
K1 enfermedad celíaca
K1 células dendríticas
K1 2412 Inmunología
K1 3205.03 Gastroenterología
K1 2407 Biología Celular
AB Dendritic cells (DC) and macrophages (Mϕ) constitute the most abundant antigen presenting cells in the human intestinal mucosa. In resting conditions, they are essential to maintain the mechanisms of immune tolerance toward food antigens and commensals, at the time that they keep the capacity to initiate and maintain antigen-specific pro-inflammatory immune responses toward invading pathogens. Nevertheless, this delicate equilibrium between immunity and tolerance is not perfect, like in coeliac disease (CD), where DC and Mϕ drive the development of antigen-specific immune responses toward dietary gluten peptides. In this review, we provide therefore a comprehensive discussion about CD pathogenesis, the human intestinal immune system and the biology of intestinal DC and Mϕ both in resting conditions and in CD. Last, but not least, we discuss about all the remaining issues pending to be studied regarding DC and Mϕ contribution toward CD pathogenesis. This may allow the identification of unique and specific factors which may be useful in the clinical practice, as well as identify new therapeutic targets in order to reestablish the loss intestinal homeostasis in CD.
PB Elsevier
SN 978-0-323-85311-8
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/65831
UL https://uvadoc.uva.es/handle/10324/65831
LA eng
NO Immunopathology of Celiac Disease. Edited by Ainara Castellanos-Rubio, Lorenzo Galluzzi. International Review of Cell and Molecular Biology Volume 358, 2021, Pages 85-104
NO Producción Científica
DS UVaDOC
RD 17-may-2024