RT info:eu-repo/semantics/article
T1 Moderate ethanol ingestion, redox status, and cardiovascular system in the rat
A1 Vega Agapito, Mª Victoria
A1 Gonzalez Martín, Mª Carmen
A1 Obeso Caceres, Ana
A1 Preito Lloret, Jesús
A1 Bustamente, Rosa
A1 Castañeda, Javier
A1 Agapito Serrano, Teresa
A1 González, Constancio
K1 Oxygen reactive species (ROS); Antioxidant enzymes; Cardiovascular system; Pulmonary arterial hypertension; Cholesterol; Cytochrome
AB Moderate intake of alcoholic beverages decreases the incidence of cardiovascular pathologies, but it is in dispute if cardioprotectiveeffects are due to ethanol, to polyphenolic compounds present in beverages or to a combination of both. In humans, effects of high,moderate, and low doses of alcoholic beverages are widely studied, but effects of pure alcohol remain unclear. On the other hand, experimentswith laboratory animals are centered on high toxicological doses of ethanol but not on low doses. In the present study, we have aimedto mimic in the rat the pattern of alcohol intake in Mediterranean population. Alcohol ingestion is spread along the day and not alwaysrelated to solid food consumption. We tried to define the beneficial and harmful effects of pure ethanol ingestion without polyphenol’s influence.Experimental rats were given 1% ethanol in their drinking water for 30 days, resulting in a daily ingestion of 0.27 mL of ethanol/rat/d.Ethanol ingestion did not cause deleterious effects on the general status of the animals, but it decreased cholesterol, triglycerides, and catecholaminestores’ rate of utilization in peripheral sympathetic system. Moreover, ethanol lowered pulmonary arterial pressure and did notalter systemic arterial pressure. In the liver, the reduced glutathione/oxidized glutathione ratio was augmented and lipid peroxide, superoxidedismutase, and glutathione peroxidase activities were decreased. However, catalase activity was unaltered. Liver cytochromeP4502E1 distribution and protein level and activity were unchanged by ethanol ingestion. Data indicate a lack of harmful effects and underscorea set of potentially beneficial effects of this dose of ethanol.
PB Elsevier
YR 2011
FD 2011-06
LK https://uvadoc.uva.es/handle/10324/65859
UL https://uvadoc.uva.es/handle/10324/65859
LA eng
NO Alcohol, junio 2011, 45, pp381-391
NO Producción Científica
DS UVaDOC
RD 01-jun-2024