Dpto. Química Orgánica - Capítulos de monografías https://uvadoc.uva.es/handle/10324/1409 2026-04-13T20:57:19Z 2026-04-13T20:57:19Z Parte, Lucía G. Fernández Peña, Laura Díez Poza, Carlos Guerra Navarro, Francisco Javier López Hernández, Enol https://uvadoc.uva.es/handle/10324/80392 2025-12-09T20:01:03Z 2025-01-01T00:00:00Z

The integration of homogeneous catalytic methodologies in continuous flow have provided during the last decades new synthetic opportunities for organic chemists. A plethora of organocatalytic and transition-metal catalyzed transformations has been described to access to underexplored chemical space and have improved reaction times and selectivities to custom complex small molecules. These chemical approaches have been also described for the preparation of active pharmaceutical ingredients (APIs) not only for specific organic scaffolds but also in scale-up versions of valuable molecules.

2025-01-01T00:00:00Z Guerra Navarro, Francisco Javier Barbero Pérez, María Asunción Fernández Peña, Laura https://uvadoc.uva.es/handle/10324/72519 2025-02-07T13:57:15Z 2021-01-01T00:00:00Z

Seven-membered rings oxacycles are motifs abundant in natural products with interesting biological properties. The literature contains a myriad of works focused on synthetic routes to achieve this type of skeleton that thermodynamically is less favored than five or six members’ counterparts. This article aims at illustrating the main strategies addressed to master the synthesis of oxepanes and oxepines reviewing the works published in the field between 2008 and 2020.

2021-01-01T00:00:00Z Pedrosa Sáez, Rafael Andrés García, José María https://uvadoc.uva.es/handle/10324/21453 2021-06-23T11:57:34Z 2015-01-01T00:00:00Z

Prolinamides are valuable organocatalysts for enantioselective transformations that occur by activation of the nucleophile by enamine formation. Different substituents can be appended on the nitrogen atom of the carboxamide, which allow for the modulation of the catalytic properties. In that way, the acidity, the hydrogen donor properties, the hydrophobicity, or the chiral environment can be modified, in a few steps, starting from easily available proline.

2015-01-01T00:00:00Z