BIOFORGE - Capítulos de monografíasBIOFORGE - Capítulos de monografíashttps://uvadoc.uva.es/handle/10324/228242026-04-05T19:34:45Z2026-04-05T19:34:45ZDesigning elastin-like recombinamers for rherapeutic and regenerative purposesRodríguez Cabello, José CarlosEscalera Anzola, SaraJuanes Gusano, DianaSantos García, María MercedesGirotti ., Alessandrahttps://uvadoc.uva.es/handle/10324/748512025-02-05T20:01:14Z2022-01-01T00:00:00ZElastin-like recombinamers (ELRs) are proteinaceous biopolymers obtained by recombinant technology and which sequence is inspired by natural elastin. Genetic engineering allows total control over amino acid sequence and design of ELR structures in a versatile way that can include bioactive, structural, or functional domains. ELRs can be used as precursors of bioactive and biocompatible hydrogels generated by either physical or chemical interchain cross-linking. This chapter describes ELR-based hydrogels, their principal features, and applications in biomedical field. We focus on the use of these hydrogels as advanced scaffolds mimicking extracellular matrix in tissue engineering, reviewing the most interesting and recent examples of musculoskeletal, cardiovascular, skin, and neural tissue regeneration. Advanced drug delivery devices based on ELRs hydrogels are also reviewed concerning their application in disease therapies, such as type 2 diabetes, ischemia, or glaucoma, and focusing mainly on cancer therapy.
2022-01-01T00:00:00ZChemical modification of biomaterials from natureRodríguez Cabello, José CarlosGonzález de Torre, IsraelSantos García, María MercedesTestera Gorgojo, Ana MaríaAlonso Rodrigo, Matildehttps://uvadoc.uva.es/handle/10324/748502025-02-05T20:01:13Z2016-01-01T00:00:00ZProtein modification is an area of an intense research and many methods have been developed with applications in fields including biology, chemistry and medicine, as they are powerful tools for studying protein expression and localization, and engineering the functions of protein both in vitro and in live cells or in vivo to create new biocatalysts and bioanalytical tools. There are different high precision protein modification methods which can be roughly divided into two categories. The first involve the use of a genetic modification system and the second is based on the labeling of expressed proteins taking advantages of the chemical reactivity of the amino acid side chains. As they occur after the protein biosynthesis step, these chemical modifications, are commonly referred to as post-translational modifications (PTMs). Natural polysaccharides and their derivatives are emerging polymers in pharmaceutical and biomedical fields such as tissue engineering, particularly for cartilage, drug delivery devices and gel-entrapment systems for cells immobilization.
2016-01-01T00:00:00ZBioactive and smart hydrogel surfacesRodríguez Cabello, José CarlosFernández Colino, AliciaPiña Lancho, María JesúsAlonso Rodrigo, MatildeSantos García, María MercedesTestera Gorgojo, Ana Maríahttps://uvadoc.uva.es/handle/10324/748492025-02-06T07:08:02Z2013-01-01T00:00:00ZRecently, hydrogels have become popular in material research for biomedical applications, such as tissue engineering. In nature, tissues are formed by cells that are surrounded by the extracellular matrix (ECM). One of its components is the elastin. Such proteins can be used to create new polymers known as elastin-like recombinamers (ELRs), which can be utilized to create hydrogels. These bioinspired materials not only mimic the native ECM but also improve their natural properties, making them bioactive and sensitive to their environment.
Herein, we review hydrogels as three-dimensional scaffolds focusing on ELRs and their potential as materials for different applications in the biomedical field.
2013-01-01T00:00:00ZDevelopments in recombinant silk and other elastic protein fibers for textile and other applicationsRodríguez Cabello, José CarlosGarcía Arévalo, CarmenMartín Maroto, LauraSantos García, María MercedesReboto Rodríguez, Virginiahttps://uvadoc.uva.es/handle/10324/748482025-02-05T20:01:12Z2010-01-01T00:00:00ZThe ability to manipulate genes and their products by recombinant DNA has signaled a number of new possibilities for the production of modified or new fibrous biopolymers or protein-based polymers with a combination of strength and elasticity similar or even superior to that of synthetic high-tech fibers. Biotechnological approaches offer the opportunity to replace existing chemical or mechanical processes for a cleaner production technology than conventional procedures, which cause severe pollution problems from textile effluents.
2010-01-01T00:00:00ZRecombinant antimicrobial peptidesRodríguez Cabello, José CarlosGarcía Arévalo, CarmenGirotti ., AlessandraSantos García, María Mercedeshttps://uvadoc.uva.es/handle/10324/748472025-02-06T07:09:10Z2011-01-01T00:00:00ZThis chapter contains sections titled: Introduction - Recombinant Routes for the Generation of Novel AMPs - Compositional and Structural Requirements for AMP Activity - Applications of AMPs - References
2011-01-01T00:00:00Z